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Prognostic value of the immunohistochemical expression of vascular endothelial growth factors in malignant salivary gland neoplasms:a systematic review and meta-analysis

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Prognostic value of the immunohistochemical expression of vascular endothelial growth factors in malignant salivary gland neoplasms:a systematic review and meta-analysis

dc.contributor.author	dos Santos, Erison-Santana	es
dc.contributor.author	Ramos, Joab Cabral	es
dc.contributor.author	Normando, Ana Gabriela Costa	es
dc.contributor.author	Paes Leme, Adriana Franco	es
dc.date.accessioned	2023-06-16T08:36:37Z
dc.date.available	2023-06-16T08:36:37Z
dc.date.issued	2021	es
dc.identifier.citation	dos Santos, ES., Ramos, JC., Normando, AG., & Leme, AF. (2021). Prognostic value of the immunohistochemical expression of vascular endothelial growth factors in malignant salivary gland neoplasms: a systematic review and meta-analysis. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e126-e135). Medicina Oral, S.L. https://doi.org/10.4317/medoral.23974	es
dc.identifier.uri	https://hdl.handle.net/10550/88004
dc.description.abstract	The immunohistochemical expression of vascular endothelial growth factor is a prognostic marker in several cancer types. In salivary gland tumors, the association between vascular endothelial growth factor and prognosis remains unclear. The purpose of this study was to perform a systematic review and meta-analysis to assess whether the immunohistochemical expression of vascular endothelial growth factor in patients with salivary gland neoplasms presents prognostic value. Immunohistochemical studies assessing the predictive value of vascular endothelial growth factor in salivary gland neoplasms were systematically reviewed using PubMed, Scopus, Embase, Cochrane Library, and Web of Science databases. It was assessed any survival rates. The fixed-effect model with an adjusted hazard ratio (HR) and 95% confidence intervals (95% CI) as effect measures were performed in the meta-analysis. The Quality in Prognosis Studies (QUIPS) tool was used to assess the quality of the included studies, and the evidence quality was assessed by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system. The immunohistochemical overexpression of vascular endothelial growth factor in patients with salivary gland neoplasms was associated with shortened survival (HR=5.37, 95% CI: 2.67-10.83, P = 0.00001). In addition, the presence of vascular endothelial growth factor was tightly associated with tumor size, lymph node metastasis, clinical stage, perineural invasion, vascular invasion, poor local control of the disease, and recurrence. The immunohistochemical overexpression of vascular endothelial growth factor in patients with salivary gland neoplasms has prognostic value and was associated with decreased survival time. However, more primary well-designed studies are necessary to increase the level of evidence.	es
dc.subject	molar	es
dc.subject	third	es
dc.subject	sex	es
dc.subject	tooth extraction	es
dc.title	Prognostic value of the immunohistochemical expression of vascular endothelial growth factors in malignant salivary gland neoplasms:a systematic review and meta-analysis	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23974	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980300/