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Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial

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Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial

dc.contributor.author	Martins-de-Barros, Allan Vinícius	es
dc.contributor.author	Barros, Ana Maria Ipólito	es
dc.contributor.author	de Siqueira, Anna Karolline Cadengue	es
dc.contributor.author	Lucena, Eudes Euler de Souza	es
dc.contributor.author	Sette de Souza, Pedro Henrique	es
dc.contributor.author	Araújo, Fábio Andrey da Costa	es
dc.date.accessioned	2023-06-16T08:36:38Z
dc.date.available	2023-06-16T08:36:38Z
dc.date.issued	2021	es
dc.identifier.citation	Martins-de-Barros, AV., Barros, AM., Siqueira, AK., Lucena, EE., Sette de Souza, PH., & Araújo, FA. (2021). Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e141-e150). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24088	es
dc.identifier.uri	https://hdl.handle.net/10550/88006
dc.description.abstract	The preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the potential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare the efficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibular third molar removal. The researches implemented a triple-blind, randomized clinical trial. The study was conducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to two interventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before the procedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome variable was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variables were the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test for paired samples were used to compare the means. Significance was set at p < 0.05. Fifty individuals were randomized and allocated to intervention, and the sample was composed of 40 subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac tromethamine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and trismus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). The clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibular third molar removal was superior to ketorolac tromethamine?s.	es
dc.subject	orthognathic surgery	es
dc.subject	intermediate splint	es
dc.subject	accuracy	es
dc.subject	intermaxillary fixation	es
dc.subject	bone screw	es
dc.title	Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24088	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980286/