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Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars:a double-blind, split-mouth, randomised controlled trial

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Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars:a double-blind, split-mouth, randomised controlled trial

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dc.contributor.author Larsen, Marie Kjærgaard es
dc.contributor.author Kofod, Thomas es
dc.contributor.author Duch, Kirsten es
dc.contributor.author Starch-Jensen, Thomas es
dc.date.accessioned 2023-06-16T08:36:38Z
dc.date.available 2023-06-16T08:36:38Z
dc.date.issued 2021 es
dc.identifier.citation Larsen, MK., Kofod, T., Duch, K., & Starch-Jensen, T. (2021). Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars: a double-blind, split-mouth, randomised controlled trial. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e156-e163). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24094 es
dc.identifier.uri https://hdl.handle.net/10550/88008
dc.description.abstract The objective of the present study was to compare the efficacy of different doses of methylprednisolone on postoperative sequelae and quality of life (QoL) following surgical removal of mandibular third molars (SRM3). Fifty-two patients (16 men and 36 women, mean age 25.9 years, range: 18-39) with bilateral impacted mandibular third molars were randomly allocated into intraoperative muscular injection of either 20mg, 30mg, 40mg methylprednisolone or saline injection. Baseline measurements were obtained preoperatively and compared with assessment after one day, three days, seven days and one month. Pain and trismus were estimated by visual analog scale score and interincisal mouth opening, respectively. Subjective assessment of QoL included Oral Health Impact Profile (OHIP-14). Descriptive and generalized estimating equation analyses were made and expressed as mean values with a 95% confidence interval. Methylprednisolone revealed no significant differences in pain, trismus and QoL compared with placebo. Higher prevalence of postoperative pain and worsening in QoL were observed with increased age (P=0.00). Smoking and increased time of surgery decreased mouth opening in the early healing phase (P=0.00). The present study revealed no significant improvement of methylprednisolone on postoperative sequelae and QoL following SRM3 compared with placebo. es
dc.subject oral health es
dc.subject case control study es
dc.subject sleep es
dc.subject review es
dc.subject gingivitis es
dc.subject periodontitis es
dc.subject tooth loss es
dc.title Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars:a double-blind, split-mouth, randomised controlled trial es
dc.type journal article es_ES
dc.subject.unesco UNESCO:CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.24094 es
dc.type.hasVersion VoR es_ES
dc.identifier.url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980302/

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