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Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma

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Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma

dc.contributor.author	Sánchez-Romero, Celeste	es
dc.contributor.author	Pereira Prado, Vanesa	es
dc.contributor.author	Sicco, Estefanía	es
dc.contributor.author	Suarez, Mariana	es
dc.contributor.author	Tapia-Repetto, Gabriel	es
dc.contributor.author	Carreón-Burciaga, Ramón	es
dc.contributor.author	González González, Rogelio	es
dc.contributor.author	Villarroel Dorrego, Mariana	es
dc.contributor.author	Meleti, Marco	es
dc.contributor.author	Molina Frechero, Nelly	es
dc.contributor.author	Bologna Molina, Ronell	es
dc.date.accessioned	2023-06-16T08:36:38Z
dc.date.available	2023-06-16T08:36:38Z
dc.date.issued	2021	es
dc.identifier.citation	Sánchez-Romero, C., Pereira-Prado, V., Sicco, E., Suarez, M., Tapia-Repetto, G., Carreón-Burciaga, R., Gónzalez-Gónzalez, R., Villarroel-Dorrego, M., Meleti, M., Molina-Frechero, N., & Bologna-Molina, N. (2021). Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e238-e245). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24151	es
dc.identifier.uri	https://hdl.handle.net/10550/88017
dc.description.abstract	The caveolin-1 protein (structural component of membrane caveolae) plays important roles in several biological functions, such as endocytosis, cell adhesion, and cell signaling. However, this protein has been associated with mechanisms of tumorigenesis in several neoplasms. The expression patterns and roles of caveolin-1 in the oral epithelium and in embryonic and odontogenic tumor tissues are still unclear. The expression of caveolin-1 was evaluated in samples of the normal gingival epithelium (n=7), human tooth germ (TG) (n=12), ameloblastoma (AM) (n=83), and ameloblastic carcinoma (AC) (n=9) by immunohistochemistry. Additionally, AM samples were analyzed by qRT-PCR and Western blot. Most TG (91.7%), AM (73.5%) and AC (100%) samples showed diverse patterns of immunohistochemical positivity for caveolin-1, while only one gingival sample was positive. The transcript levels of cav-1 were significantly upregulated by 14.9-fold in AM tissue (P = 0.0014) compared to those in normal gingival epithelial tissue, as shown by qRT-PCR. Presence of caveolin-1 protein was confirmed by Western blot analysis. The caveolin-1 immunoexpression patterns throughout the stages of TG show its importance during odontogenesis. The overexpression of caveolin-1 in AM and AC compared to its expression in normal gingival epithelium (adult tissue) suggests a possible role of caveolin-1 in protumoral events, but due to the similar immunoexpression observed in AM and AC, caveolin-1 may not necessarily participate in the malignant transformation process. However, future studies are needed to clarify and confirm these hypotheses.	es
dc.subject	desmoplastic ameloblastoma	es
dc.subject	mixed radiopaque ? radiolucent	es
dc.subject	odontogenic tumors	es
dc.subject	recurrence	es
dc.subject	enucleation	es
dc.subject	curettage	es
dc.subject	resection	es
dc.title	Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24151	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980299/