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Malignant transformation of oral leukoplakia:a multicentric retrospective study in Brazilian population

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Malignant transformation of oral leukoplakia:a multicentric retrospective study in Brazilian population

dc.contributor.author	Cerqueira, João Mateus Mendes	es
dc.contributor.author	Corrêa Pontes, Flávia Sirotheau	es
dc.contributor.author	Santos Silva, Alan Roger	es
dc.contributor.author	Almeida, Oslei Paes de	es
dc.contributor.author	Costa, Rafael Ferreira e	es
dc.contributor.author	Fonseca, Felipe Paiva	es
dc.contributor.author	Gomez, Ricardo Santiago	es
dc.contributor.author	Neto, Nicolau Conte	es
dc.contributor.author	Miyahara, Ligia Akiko Ninokata	es
dc.contributor.author	Rodrigues-Fernandes, Carla-Isabelly	es
dc.contributor.author	Neto, Elieser de Melo Galvão	es
dc.contributor.author	Araújo, Anna Luiza Damaceno	es
dc.contributor.author	Lopes, Márcio Ajudarte	es
dc.contributor.author	Rebelo-Pontes, Hélder-Antônio	es
dc.date.accessioned	2023-06-16T08:36:39Z
dc.date.available	2023-06-16T08:36:39Z
dc.date.issued	2021	es
dc.identifier.citation	Cerqueira, JM., Pontes, FS., Santos-Silva, AR., Almeida, OP., Costa, RF., Fonseca, FP., Gomez, RS., Neto, NC., Miyahara, LA., Rodrigues-Fernandes, CI., Neto, CI., & Araújo, AL. (2021). Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e292-e298). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24175	es
dc.identifier.uri	https://hdl.handle.net/10550/88024
dc.description.abstract	Among the oral potentially malignant disorders, leukoplakia stands out as the most prevalent. The purpose of this study was to analyse the clinical-pathological features of oral leukoplakia in groups of patients from three major pathology centers in two different regions of Brazil, in order to determine which factors would be associated to the clinical risk of malignant transformation. A total of 148 patients was analyzed, and data regarding gender, age, site, classification of the clinical subtype, harmful habits such as use of tobacco and alcohol, time of evolution and presence of dysplasia were collected. The association between risk factors and malignant transformation was investigated using the chi-square test and Fischer's exact test for correlation of variables. A significance level of 5% (p?0.05) was used. The mean age of the patients was 60 years, and 56% were female. Most of the lesions (34,5%) were located in the lateral and ventral regions of the tongue. Of the 148 patients, ninety had clinical follow-up. Malignant transformation occurred in 13 patients (8.8%), with an average of 44 months of follow up. Non-smoker, nonhomogeneous clinical presentation, location at the tongue, and the presence of high degree of dysplasia were statistically relevant factors associated with a higher risk of transformation transformation.	es
dc.subject	mucositis	es
dc.subject	oncology	es
dc.subject	pediatric dentistry	es
dc.title	Malignant transformation of oral leukoplakia:a multicentric retrospective study in Brazilian population	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24175	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141311/