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Proposal for a preventive protocol for medication-related osteonecrosis of the jaw

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Proposal for a preventive protocol for medication-related osteonecrosis of the jaw

dc.contributor.author	Romero Ruiz, Manuel María	es
dc.contributor.author	Romero Serrano, Marta	es
dc.contributor.author	Serrano González, Ascensión	es
dc.contributor.author	Serrera Figallo, María Angeles	es
dc.contributor.author	Gutiérrez Pérez, José Luis	es
dc.contributor.author	Torres Lagares, Daniel	es
dc.date.accessioned	2023-06-16T08:36:39Z
dc.date.available	2023-06-16T08:36:39Z
dc.date.issued	2021	es
dc.identifier.citation	Romero-Ruiz, MM., Romero-Serrano, M., Serrano-González, A., Serrera-Figallo, MÁ., Gutiérrez-Pérez, JL., & Torres-Lagares, D. (2021). Proposal for a preventive protocol for medication-related osteonecrosis of the jaw. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e314-e326). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24197	es
dc.identifier.uri	https://hdl.handle.net/10550/88027
dc.description.abstract	Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some patients exposed to certain drugs (antiresorptives such as bisphosphonates or denosumab, and antiangiogenic drugs). From a review of the literature it appears that there is no uniform criterion when selecting preventive measures; these vary according to author. Likewise, the measures recommended are usually general, so that in few cases they result in specific actions to be applied depending on the different variables involved such as the type of drug used, the duration of its application, the underlying pathology, the presence or absence of risk factors, etc. The aim of this study has been to design a preventive protocol which can be easily applied in any clinic or by any dental care service. We undertook an exhaustive literature review to find any articles related to the topic of study, namely, preventive measures for medication-related osteonecrosis of the jaw, on the one hand generically and on the other focusing on dental implant treatment. The most part the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. From 3946 items, we selected a total of 21 items. From the analysis of the selected articles, several protocols have been developed that are easy to apply in a dental clinic.: Protocol 1. Before starting treatment with antiresorptives (Patients who are going to be treated for osteoporosis / Patients who are going to be treated for cancer). Protocol 2. Once treatment is initiated with antiresorptives (Patients being treated for osteoporosis / Patients being treated for cancer). The application of these protocols requires an interdisciplinary team which can handle the various treatments and apply the measures contained in them. Along with a team of well-educated and trained dentists, it is equally important to maintain contact with the medical team involved in the treatment of the underlying pathology, especially rheumatologists, oncologists, internists and gynaecologists. All the above requires a great staff learning and organization effort, continuous training and coordination of the whole team involved in the preventive management of these patients.	es
dc.subject	dental implant	es
dc.subject	edentulism	es
dc.subject	older people	es
dc.subject	sleep disturbances	es
dc.title	Proposal for a preventive protocol for medication-related osteonecrosis of the jaw	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24197	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141321/