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Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population

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Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population

dc.contributor.author	Rosa, Roberta-Rezende	es
dc.contributor.author	Garcia, Marcelo Augusto Junior	es
dc.contributor.author	Alves, Patrícia Terra	es
dc.contributor.author	Sousa, Elisa Moraes	es
dc.contributor.author	Pimentel, Letícia Santos	es
dc.contributor.author	Barbosa, Luciana de Paula	es
dc.contributor.author	Loyola, Adriano-Mota	es
dc.contributor.author	Goulart Filho, Luiz Ricardo	es
dc.contributor.author	de Faria, Paula Cristina Batista	es
dc.contributor.author	Vitorino Cardoso, Sérgio	es
dc.date.accessioned	2023-06-16T08:36:40Z
dc.date.available	2023-06-16T08:36:40Z
dc.date.issued	2021	es
dc.identifier.citation	Rosa, RR., Garcia, MA., Alves, PT., Sousa, EM., Pimentel, LS., Barbosa, Ld., Loyola, AM., Goulart, LR., Faria, PC., & Cardoso, SV. (2021). Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e334-e340). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24215	es
dc.identifier.uri	https://hdl.handle.net/10550/88029
dc.description.abstract	Metallothioneins (MTs) gene polymorphisms have been associated with the ability of free radical scavenging and detoxification of heavy metals leading to cancer development. Our aim was to revisit, in a Brazilian population, single-nucleotide polymorphisms (SNPs) of the MT gene family previously associated with oral squamous cell carcinoma (OSCC). A case-control investigation with 28 OSCC patients and 45 controls was conducted, using conventional risk factors (tobacco use and alcohol consumption) as covariates. SNPs genotyping for rs8052334 (MT1B), rs964372 (MT1B), and rs1610216 (MT2A) was performed by PCR-RFLP, and SNPs for rs11076161 (MT1A) were analyzed by TaqMan assay. The only SNP associated with increased risk for OSCC was the MT-1A AA genotype (OR = 4.7; p = 0.01). We have also evidenced for the first time a significant linkage disequilibrium between the SNPs of MT-2A and MT-1A in this population with the highest frequency (30%) of the unfavorable haplotype G/A/C/T (rs1610216 / rs11076161 / rs964372 / rs8052334) of MT gene polymorphisms (OR = 6.2; p = 0.04). Interestingly, after removing the effects of conventional risk factors, we have uncovered the significance of the AA genotype of the rs11076161 with increased odds of 19-fold higher towards OSCC development. This is the first demonstration that a significant linkage disequilibrium among gene polymorphisms of the MT family may affect susceptibility to oral cancer, which is conditioned by the G/A/C/T haplotype (rs1610216/rs11076161/rs964372/ rs8052334) and the MT-1A gene polymorphism has a potential clinical utility for the OSCC risk assessment.	es
dc.subject	controlled clinical trial	es
dc.subject	gallium aluminium arsenide lasers	es
dc.subject	third molar	es
dc.title	Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24215	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141308/