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Primary melanoma of the oral cavity:a multi-institutional retrospective analysis in Brazil

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Primary melanoma of the oral cavity:a multi-institutional retrospective analysis in Brazil

dc.contributor.author	Rodrigues, Bruno-Teixeira-Gonçalves	es
dc.contributor.author	Cunha, John Lennon Silva	es
dc.contributor.author	Albuquerque, Danielle Mendes da Silva	es
dc.contributor.author	Chagas, Wagner Pinto das	es
dc.contributor.author	Freire, Nathália de Almeida	es
dc.contributor.author	Agostini, Michelle	es
dc.contributor.author	Canedo, Nathalie Henriques Silva	es
dc.contributor.author	Albuquerque-Júnior, Ricardo-Luiz-Cavalcanti	es
dc.contributor.author	Sousa, Sílvia Ferreira	es
dc.contributor.author	Corrêa-Abrahão, Aline	es
dc.contributor.author	Romañach, Mário José	es
dc.contributor.author	Almeida, Oslei Paes de	es
dc.contributor.author	Israel, Mônica Simões	es
dc.contributor.author	Andrade, Bruno Augusto Benevenuto de	es
dc.date.accessioned	2023-06-16T08:36:40Z
dc.date.available	2023-06-16T08:36:40Z
dc.date.issued	2021	es
dc.identifier.citation	Rodrigues, BT., Cunha, JL., Albuquerque, DM., Chagas, WP., Freire, Nd., Agostini, M., Canedo, NH., Albuquerque Júnior, RL., de Sousa, SF., Abrahão, AC., Romañach, AC., & Almeida, OP. (2021). Primary melanoma of the oral cavity: A multi-institutional retrospective analysis in Brazil. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e379-e386). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24240	es
dc.identifier.uri	https://hdl.handle.net/10550/88035
dc.description.abstract	Melanoma is an aggressive malignant tumor, rarely observed in the oral cavity. The aim of this study was to describe the clinicopathologic features of a series of oral melanomas. A retrospective descriptive study was performed. A total of 15,482 biopsy records from two oral and maxillofacial pathology services in Brazil were analyzed. All cases of oral melanomas were reviewed, and clinical, demographic, histopathological data, treatment, and follow-up status were collected. In addition, immunohistochemistry stains (pan-cytokeratin AE1/AE3, vimentin, ?-SMA, CD45, S-100 protein, HMB-45, Melan A, and Ki-67) were performed. The series comprised of 5 males (71.4%) and 2 females (28.6%), with a mean age of 58.0 ± 9.2 years (range: 45-69 years) and a 2.5:1 male-to-female ratio. The gingiva (n = 3, 42.8%) and hard palate (n = 2, 28.6%) were the most common affected sites, presenting clinically as ulcerated swellings with a brown to black color. Cervical lymph node metastasis was detected in three patients during the first examination. Microscopically, 6 cases (85.7%) were melanotic, and one (14.3%) was amelanotic. Most cases (n = 4, 57.1%) presented a predominance of epithelioid cells. S-100 and HMB-45 were positive in all cases (n = 7, 100.0%). In contrast, only 4 cases (57.1%) were positive for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 70.0% to more than 90% of positive cells. Five patients died from complications of the tumors after a mean follow-up period of 7.8 months. Melanoma is an aggressive malignant tumor that rarely occurs in the oral cavity. It occurs mainly in adult and elderly patients and often is diagnosed in advanced stages. The current findings were similar to previous studies and reflected the characteristics of the services from where lesions were retrieved.	es
dc.subject	head and neck cancer	es
dc.subject	oral cancer	es
dc.subject	oral squamous cell carcinoma	es
dc.subject	survival	es
dc.subject	prognosis	es
dc.title	Primary melanoma of the oral cavity:a multi-institutional retrospective analysis in Brazil	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24240	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141310/