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Salivary gland cancer in Southern Brazil:a prognostic study of 107 cases

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Salivary gland cancer in Southern Brazil:a prognostic study of 107 cases

dc.contributor.author	Zanella, Virgilio Gonzales	es
dc.contributor.author	Wagner, Vivian Petersen	es
dc.contributor.author	Schmidt, Tuany Rafaeli	es
dc.contributor.author	Thieme, Stefanie	es
dc.contributor.author	Correa, Cintia	es
dc.contributor.author	Fonseca, Felipe Paiva	es
dc.contributor.author	Rigon, Pettala	es
dc.contributor.author	Barra, Marinez Bizarro	es
dc.contributor.author	Kroef, Ricardo Gallicchio	es
dc.contributor.author	Vargas, Pablo Agustín	es
dc.contributor.author	Martins, Manoela D.	es
dc.date.accessioned	2023-06-16T08:36:40Z
dc.date.available	2023-06-16T08:36:40Z
dc.date.issued	2021	es
dc.identifier.citation	Zanella, VG., Wagner, VP., Schmidt, TR., Thieme, S., Correa, C., Fonseca, FP., Rigon, P., Barra, MB., Kroef, RG., Vargas, PA., & Martins, PA. (2021). Salivary gland cancer in Southern Brazil: a prognostic study of 107 cases. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e393-e403). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24248	es
dc.identifier.uri	https://hdl.handle.net/10550/88037
dc.description.abstract	Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south of Brazil aiming to determine the prognostic value of demographic, clinic and pathologic features. Cases diagnosed as SGC between 2006 and 2016 were retrospectively collected. Medical records were examined to extract demographic, clinic, pathologic and follow-up information. One-hundred and seven cases of SGC were identified. The most common SGC were mucoepidermoid carcinoma (MEC) (n = 39) followed by adenoid cystic carcinoma (AdCC) (n = 29). Among AdCCs, 55.2% of cases were classified as cribriform, 27.6% as tubular and 17.2% as solid. The tubular subtype had the highest percentage of cases with perineural invasion (p=0.01). Among MEC, 61.5% of cases were classified as low grade, 15.4% as intermediate grade and 19.9% as high grade. Low grade MEC had the lowest percentage of cases with perineural invasion (p=0.04). The 5-year survival for loco-regional control, disease-free survival (DFS) and disease-specific survival were 75%, 70% and 84%, respectively. The following features were associated with poor DFS: advanced age (p=0.03), rural residency (p=0.01), being a smoker or former smoker (p=0.01), pain (p=0.03), nodal metastasis (p <0.001), need for chemotherapy (p=0.02), neck dissection (p=0.04), perineural invasion (p=0.01), and being diagnosed with AdCC compared to MEC (p=0.02). The clinco-demographic and pathologic features identified as prognostic factors reveal the profile of patients at increased risk of recurrence and who would benefit from closer follow-up.	es
dc.subject	sjögren syndrome	es
dc.subject	xerostomia	es
dc.subject	salivary glands	es
dc.title	Salivary gland cancer in Southern Brazil:a prognostic study of 107 cases	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24248	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141320/