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Periodontitis as a risk factor for head and neck cancer

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Periodontitis as a risk factor for head and neck cancer

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dc.contributor.author Gasparoni, Letícia Miquelitto es
dc.contributor.author Abreu Alves, Fabio es
dc.contributor.author Holzhausen, Marinella es
dc.contributor.author Pannuti, Claudio es
dc.contributor.author Serpa, Marianna-Sampaio es
dc.date.accessioned 2023-06-16T08:36:41Z
dc.date.available 2023-06-16T08:36:41Z
dc.date.issued 2021 es
dc.identifier.citation Gasparoni, LM., Alves, FA., Holzhausen, M., Pannuti, CM., & Serpa, MS. (2021). Periodontitis as a risk factor for head and neck cancer. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e430-e436). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24270 es
dc.identifier.uri https://hdl.handle.net/10550/88042
dc.description.abstract Periodontitis may be associated with the development of head and neck cancer (HNC). A literature review was conducted to understand the possible association between them. Articles published in the PubMed database from January 1999 and May 2020 were retrieved. Limitations of the studies and biological mechanisms were discussed. A total of 4,232 articles were found. Of these, 13 were analyzed according to inclusion criteria. Most papers found some association between periodontitis and HNC, although differences in periodontal evaluation, sample size, study design and tumor sites were observed. Porphyromonas gingivalis appears to increase the chance of both diseases, and it may be one of their main potential risk factors. Genetic predisposition is increased by exposure to environmental factors which can directly induce epigenetic changes that contribute to these diseases. Understanding the mechanisms related to periodontitis and HNC has increased, however, well-designed clinical studies are needed for better conclusions. Furthermore, the advent of multiple "omic" technologies will help comprehend their possible association. es
dc.subject oral health es
dc.subject oral health-related quality of life es
dc.subject solid organ transplantation es
dc.title Periodontitis as a risk factor for head and neck cancer es
dc.type journal article es_ES
dc.subject.unesco UNESCO:CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.24270 es
dc.type.hasVersion VoR es_ES
dc.identifier.url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254889/

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