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An observational retrospective study of odontogenic cyst´s and tumours over an 18-year period in a Portuguese population according to the new WHO Head and Neck Tumour classification

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An observational retrospective study of odontogenic cyst´s and tumours over an 18-year period in a Portuguese population according to the new WHO Head and Neck Tumour classification

dc.contributor.author	Monteiro, Luís Silva	es
dc.contributor.author	Santiago, Catarina	es
dc.contributor.author	Amaral, José Barbas do	es
dc.contributor.author	Al-Mossallami, Azza	es
dc.contributor.author	Albuquerque, Rui	es
dc.contributor.author	Simao, Joao Carlos Lopes	es
dc.date.accessioned	2023-06-16T08:36:41Z
dc.date.available	2023-06-16T08:36:41Z
dc.date.issued	2021	es
dc.identifier.citation	Monteiro, L., Santiago, C., Amaral, Bd., Al-Mossallami, A., Albuquerque, R., & Lopes, C. (2021). An observational retrospective study of odontogenic cyst´s and tumours over an 18-year period in a Portuguese population according to the new WHO Head and Neck Tumour classification. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e482-e493). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24337	es
dc.identifier.uri	https://hdl.handle.net/10550/88049
dc.description.abstract	Odontogenic cysts and tumours of the jaws represent one of the most prevalent groups of oral-maxillofacial lesions. We aimed to evaluate the clinical and pathological characteristics of a cohort of odontogenic cysts (OC) and odontogenic tumours (OT) of the jaws in a Portuguese population. This observational retrospective study analysed patients diagnosed with either an OC or OT of the jaws at a central hospital of Oporto, Portugal, between 1988 and 2006. Data collected from patients? files included demographic, clinical, radiological and histopathological information. Recurrence was evaluated using univariate and multivariate analysis. The sample consisted of 397 patients, 231 males (58.2%) and 166 females (41.8%), with a mean-age of 36.7±17 years. Twenty-seven patients (6.8%) presented with more than one lesion providing a total of 433 lesions. There were 396 (91.5%) OC, mostly represented by radicular cysts (n=257;59.4%), dentigerous cysts (n=79;18.2%), or odontogenic keratocysts (n=50;11.5%). There were 37 (8.5%) OT, mostly represented by ameloblastomas (n=16;3.7%), and odontomas (n=9;2.1%). The most common initial clinical manifestation was swelling (n=224;51.7%). Recurrence was observed in 30 cases (6.9%), mostly in ameloblastomas (n=6;37.5%) and odontogenic keratocysts (n=12;24%). In the multivariate analysis the diagnosis classification of the lesion was the only independent and significant variable related with the recurrence (P=0.04). Radicular cysts were the most commonly occurring type of OC and ameloblastomas the most commonly occurring OT. Amelobastomas and odontogenic keratocysts were the lesions with the highest rates of recurrence. This large sample provides useful information about the frequency profile and characteristics of OC and OT over a period of 18 years, allowing valuable comparison with data from other countries.	es
dc.subject	oral mucositis	es
dc.subject	pd1	es
dc.subject	pd-l1	es
dc.subject	oral cancer	es
dc.subject	immunotherapy	es
dc.title	An observational retrospective study of odontogenic cyst´s and tumours over an 18-year period in a Portuguese population according to the new WHO Head and Neck Tumour classification	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24337	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254885/