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Evaluation of saliva as a complementary technique to the diagnosis of COVID-19:a systematic review

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Evaluation of saliva as a complementary technique to the diagnosis of COVID-19:a systematic review

dc.contributor.author	Sagredo-Olivares, Katherine	es
dc.contributor.author	Morales-Gómez, Constanza	es
dc.contributor.author	Aitken Saavedra, Juan	es
dc.date.accessioned	2023-06-16T08:36:42Z
dc.date.available	2023-06-16T08:36:42Z
dc.date.issued	2021	es
dc.identifier.citation	Sagredo-Olivares, K., Morales-Gómez, C., & Aitken-Saavedra, J. (2021). Evaluation of saliva as a complementary technique to the diagnosis of COVID-19: a systematic review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e526-e532). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24424	es
dc.identifier.uri	https://hdl.handle.net/10550/88054
dc.description.abstract	Infectious disease coronavirus 2019 (COVID-19) is caused by the SARS-CoV-2 virus, and it mainly affects the upper respiratory tract. The gold standard for its diagnosis is real-time reverse transcription polymerase chain reaction (RT-qPCR) performed on a nasopharyngeal swab. In contrast, testing saliva has significant advantages as a diagnostic method. We searched for articles evaluating saliva as a diagnostic method for COVID-19 on the PUBMED/MEDLINE, WEB OF SCIENCE, COCHRANE, and SCIELO platforms. We initially found 233 articles and 20 were selected for inclusion following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol: 18 cross-sectional studies and 2 case reports, including 8 from America, 8 from Asia, and 4 from Europe. The studies evaluated the presence of viral RNA, IgG, IgM, and IgA in samples of unstimulated saliva from adults with confirmed or suspected COVID-19. The vast majority of the studies performed RT-qPCR on the saliva samples and compared the results with the gold standard (a nasopharyngeal swab of the same patient). Saliva samples analyzed by RT-qPCR, reverse transcription isothermal amplification (RT-LAMP), spectroscopy, and enzyme-linked immunosorbent assay (ELISA) offer high sensitivity to detect SARS-CoV-2 in the early stages of the disease and among asymptomatic patients as compared to nasopharyngeal swab RT-qPCR. In addition, the self-collection of saliva offers the possibility of receiving telemedicine instructions to carry out the test, reducing the risk of contagion. The diagnosis of COVID-19 through saliva is sensitive, non-invasive, and is of low risk for the healthcare professionals. However, further studies are recommended to validate its clinical use.	es
dc.subject	oral histopathology	es
dc.subject	dental undergraduate students	es
dc.subject	virtual microscopy	es
dc.subject	remote online learning	es
dc.subject	questionnaire	es
dc.title	Evaluation of saliva as a complementary technique to the diagnosis of COVID-19:a systematic review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24424	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254882/