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Dysplasia in oral lichen planus:relevance, controversies and challenges. A position paper

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Dysplasia in oral lichen planus:relevance, controversies and challenges. A position paper

dc.contributor.author	González Moles, M.A.	es
dc.contributor.author	Warnakulasuriya, Saman	es
dc.contributor.author	González-Ruiz, Isabel	es
dc.contributor.author	Ayen Rodríguez, Ángela	es
dc.contributor.author	González-Ruiz, Lucía	es
dc.contributor.author	Ruiz Avila, Isabel	es
dc.contributor.author	Ramos-García, Pablo	es
dc.date.accessioned	2023-06-16T08:36:42Z
dc.date.available	2023-06-16T08:36:42Z
dc.date.issued	2021	es
dc.identifier.citation	González-Moles, MÁ., Warnakulasuriya, S., González-Ruiz, I., Ayén, Á., González-Ruiz, L., Ruiz-Ávila, I., & Ramos-García, P. (2021). Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e541-e548). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24610	es
dc.identifier.uri	https://hdl.handle.net/10550/88056
dc.description.abstract	Patients with oral lichen planus (OLP) have an increased risk of oral cancer. For this reason, OLP is classified as an oral potentially malignant disorder. However, the precise personal (or individual) risk is unknown. Recent meta-analytical studies have reported that dysplastic OLP may transform to cancer in around 6% of cases, while the rate of transformation is lower (<1.5%) in non-dysplastic cases. The presence of epithelial dysplasia has emerged as the most powerful indicator for assessing cancer risk in oral potentially malignant disorders in routine practice. However, the general acceptance of epithelial dysplasia as an accompanying histologic feature in OLP is subject to great controversy. Many pathologists consider the presence of dysplasia as a criterion to exclude OLP when routinely reporting on this disease. This practice, widespread among oral pathology professionals, has resulted in the underestimation of the potential for malignancy of OLP. A review of the literature was carried out in order to critically analyze the relevance, controversies and challenges encountered across the diagnosis of epithelial dysplasia in OLP. 12 studies have been published examining dysplastic changes in OLP, reporting Figures ranging from 0.54% to 25% of cases with dysplasia in the first diagnostic biopsy. The diagnosis of dysplasia in the OLP poses an additional difficulty due to the fact that the affected oral epithelium per se develops changes related to autoimmune aggression. Among the most frequent histological features of OLP that develops dysplasia are basal cell hyperplasia with basaloid appearance, loss of basal cells polarity, cellular and nuclear pleomorphism and irregular stratification. Epithelial dysplasia should not be considered an exclusion criterion for OLP; its evaluation requires experienced pathologists in this field.	es
dc.subject	child	es
dc.subject	covid-19	es
dc.subject	oral mucosa	es
dc.subject	taste	es
dc.title	Dysplasia in oral lichen planus:relevance, controversies and challenges. A position paper	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24610	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254877/