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Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study

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Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study

dc.contributor.author	Peña Cardelles, Juan Francisco	es
dc.contributor.author	Pozo Kreilinger, Jose Juan	es
dc.contributor.author	Roncador, Giovanna	es
dc.contributor.author	Esteban Hernández, Jesús	es
dc.contributor.author	Cebrián Carretero, José Luis	es
dc.contributor.author	Moro Rodríguez, José Ernesto	es
dc.date.accessioned	2023-06-16T08:36:43Z
dc.date.available	2023-06-16T08:36:43Z
dc.date.issued	2021	es
dc.identifier.citation	Peña-Cardelles, JF., Pozo-Kreilinger, JJ., Roncador, G., Esteban-Hernández, J., Cebrián-Carretero, JL., & Moro-Rodríguez, JE. (2021). Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e651-e660). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24659	es
dc.identifier.uri	https://hdl.handle.net/10550/88071
dc.description.abstract	The search for treatments to improve cancer survival has led to the emergence of immunotherapy and the study of the tumour microenvironment existing in neoplasms. This preliminary study aims to understand the clinical and pathological relationship of clec9a expression in oral cancer and to explore survival models for future studies. Material and methods: Immunohistochemical study that included 26 patients with a diagnosis of oral squamous cell carcinoma (OSCC) in mobile tongue and floor of the mouth. Clinical and histopathological variables were recorded, and the biomarkers clec9a for dendritic cells and CD8 and CD4 for lymphocytes were used. Clec9a was expressed in 58% of the sample. It was more common in cases with low lymphoplasmacytic infiltration and in type 2 invasion patterns. It was significantly related to CD8 expression (p=0.055 and p=0.007). No prognostic risks were evident in the survival models studied (overall survival, disease-specific survival, disease-free survival). CLEC9A expression is present in the OSCC microenvironment and is mainly related to the presence of CD8 lymphocytes. The relationship of its expression with survival prognosis in OSCC could not be confirmed; however, this needs to be confirmed through future studies with larger sample size.	es
dc.subject	questionnaire	es
dc.subject	psychometric validation	es
dc.subject	head and neck cancer	es
dc.subject	pain	es
dc.subject	disability	es
dc.title	Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24659	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412449/