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Medication related osteonecrosis of the jaws (MRONJ):factors related to recurrence after treatment with surgery and platelet rich plasma (PRP) placement

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Medication related osteonecrosis of the jaws (MRONJ):factors related to recurrence after treatment with surgery and platelet rich plasma (PRP) placement

dc.contributor.author	Sánchez Gallego-Albertos, Celia	es
dc.contributor.author	Castillo Pardo de Vera, José Luis del	es
dc.contributor.author	Viejo Llorente, Aurora	es
dc.contributor.author	Cebrián Carretero, José Luis	es
dc.date.accessioned	2023-06-16T08:36:44Z
dc.date.available	2023-06-16T08:36:44Z
dc.date.issued	2021	es
dc.identifier.citation	Sánchez-Gallego Albertos, C., Del Castillo Pardo de Vera, JL., Viejo Llorente, A., & Cebrián Carretero, JL. (2021). Medication related osteonecrosis of the jaws (MRONJ): Factors related to recurrence after treatment with surgery and platelet rich plasma (PRP) placement. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e684-690). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24007	es
dc.identifier.uri	https://hdl.handle.net/10550/88075
dc.description.abstract	Medication-related osteonecrosis of the jaws (MRONJ) is a well-known complication associated with antiresorptive and antiangiogenic therapies. The purpose of this study was to analyse if there is any predictive factor of recurrence after local debridement plus platelet rich plasma (PRP) placement in MRONJ patients. Seventy MRONJ patients treated at the department of Oral and Maxillofacial Surgery in La Paz Hospital (Madrid, Spain) were included in this retrospective study. All of them were treated surgically by local debridement and PRP placement. The observation period was between January 2012 and January 2019. Information regarding use, type, administration, and duration of therapy with BP/denosumab was recorded. The follow-up period ranged from 2-52 months. A descriptive analysis, a bivariate and a multivariate study were performed. Most of the patients were women (82.9%) between 50-70 years old (64.3%), with a stage II disease (74.3%). The therapy lasted more than 12 months in 54.8% of them. Zoledronic acid was the main antiresorptive used (44.3%), followed by oral administered BPs (29 patients, 41.4%) and denosumab (10 patients, 14.3%). Osteoporosis (48.6%), breast cancer (30%) and multiple myeloma (11.4%) were the main diseases because the patients were taking antirresorptives. 13 patients (18.6%) experienced recurrence. We found that breast cancer patients (p>0.0001), smokers (p>0.016), and administration of zoledronic acid (p>0.0001) were related to recurrence. After performing the multivariate model, we found that the only factor related to recurrence was smoking habit (Wald 3.837, p=0.05, OR 6.12). recurrence after local debridement plus PRP placement in our MRONJ series affected to 18.6% of patients. It seems to be more frequent in breast cancer patients, smokers, and after zoledronic acid administration. Smoking habit was the only independent factor related to recurrence in our series.	es
dc.subject	dry socket	es
dc.subject	alveolar osteitis	es
dc.subject	treatment	es
dc.subject	management	es
dc.subject	pain control	es
dc.subject	pain relief	es
dc.title	Medication related osteonecrosis of the jaws (MRONJ):factors related to recurrence after treatment with surgery and platelet rich plasma (PRP) placement	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24007	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601641/