NAGIOS: RODERIC FUNCIONANDO

Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia:an observational cohort study

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia:an observational cohort study

dc.contributor.author	Monteiro, Luís Silva	es
dc.contributor.author	Silva, Patrícia	es
dc.contributor.author	Delgado, Maria Leonor	es
dc.contributor.author	Amaral, José Barbas do	es
dc.contributor.author	Garces, Fernanda	es
dc.contributor.author	Salazar, Filomena	es
dc.contributor.author	Pacheco, José Júlio	es
dc.contributor.author	Simao, Joao Carlos Lopes	es
dc.contributor.author	Bousbaa, Hassan	es
dc.contributor.author	Warnakulasuriya, Saman	es
dc.date.accessioned	2023-06-16T08:36:44Z
dc.date.available	2023-06-16T08:36:44Z
dc.date.issued	2021	es
dc.identifier.citation	Monteiro, L., Silva, P., Delgado, L., Amaral, B., Garcês, F., Salazar, F., Pacheco, JJ., Lopes, C., Bousbaa, H., & Warnakulasuriya, S. (2021). Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e719-e728). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24511	es
dc.identifier.uri	https://hdl.handle.net/10550/88079
dc.description.abstract	The Spindle Assembly Checkpoint (SAC) is a surveillance mechanism essential to ensure the accuracy of chromosome segregation during mitosis. Our aim was to evaluate the expression of SAC proteins in oral carcinogenesis, and to assess their potential in predicting malignant transformation of oral leukoplakia. We analysed the immunoexpression of BubR1, Mad2, Bub3, and Spindly proteins in 64 oral biopsies from 52 oral leukoplakias and 12 normal tissues. Univariate and multivariate analysis were performed to evaluate predictive factors for malignant transformation (MT). We observed that BubR1 and Mad2 were more highly expressed in high dysplasia grade lesions than in low grade or normal tissues (P<0.05). High expression of Spindly was significantly correlated with a high Ki-67 score (P=0.004). Six (11.5%) oral leukoplakias underwent malignant transformation. In univariate analysis, the binary dysplasia grade (high grade) (P<0.001) was associated with a higher risk of malignant transformation as well as high BubR1 (P<0.001) and high Mad2 (P=0.013) expression. In multivariate analysis, high expression of BubR1 and Mad2 when combined showed an increased risk for malignant transformation (P=0.013; HR of 4.6, 95% CI of 1.4-15.1). Our findings reveal that BubR1 and Mad2 were associated with an increased risk for malignant transformation independently of histological grade and could be potential and useful predictive risk markers of malignant transformation in oral leukoplakias.	es
dc.subject	oral cancer	es
dc.subject	oral dysplasia	es
dc.subject	?-catenin	es
dc.subject	wnt ligands	es
dc.subject	destruction complex	es
dc.title	Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia:an observational cohort study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24511	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601638/