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Expression profile of components of the ?-catenin destruction complex in oral dysplasia and oral cancer

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Expression profile of components of the ?-catenin destruction complex in oral dysplasia and oral cancer

dc.contributor.author	Goñi, Francisca J	es
dc.contributor.author	Peña-Oyarzún, Daniel	es
dc.contributor.author	Torres, Vicente A	es
dc.contributor.author	Reyes Rojas, Montserrat	es
dc.date.accessioned	2023-06-16T08:36:44Z
dc.date.available	2023-06-16T08:36:44Z
dc.date.issued	2021	es
dc.identifier.citation	Goñi, FJ., Peña‑Oyarzún, D., Torres, VA., & Reyes, M. (2021). Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e729-e737). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24528	es
dc.identifier.uri	https://hdl.handle.net/10550/88080
dc.description.abstract	Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, which, according to histopathological criteria, are referred to as oral dysplasia and their diagnosis are associated with higher rates of malignant transformation towards cancer. We recently reported that aberrant activation of the Wnt/??catenin pathway is due to overexpression of Wnt ligands in oral dysplasia. However, the expression of other regulators of this pathway, namely components of the ?-catenin destruction complex has not been explored in oral dysplasia. Using immunohistochemical analyses, we evaluated nuclear expression of ??catenin and its association with Wnt3a and Wnt5a. Likewise, components of the ?-catenin destruction complex, including Adenomatous Polyposis Coli (APC), Axin and Glycogen Synthase Kinase 3 beta (GSK-3?) were also evaluated in oral dysplasia and OSCC biopsies. We found that moderate and severe dysplasia samples, which harbored increased expression of nuclear ??catenin, depicted augmented cytoplasmic expression of GSK?3?, Axin and APC, in comparison with OSCC samples. Also, GSK-3? was found nuclear in mild dysplasia and OSCC samples, when compared with other study samples. Cytoplasmic levels of components of the ?-catenin destruction complex are increased in oral dysplasia and might be responsible of augmented nuclear ??catenin.	es
dc.subject	epidemiology	es
dc.subject	floor of the mouth	es
dc.subject	benign	es
dc.subject	malignant	es
dc.title	Expression profile of components of the ?-catenin destruction complex in oral dysplasia and oral cancer	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24528	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601647/