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Microtomographic reconstruction of mandibular defects treated with xenografts and collagen-based membranes:a pre-clinical minipig model

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Microtomographic reconstruction of mandibular defects treated with xenografts and collagen-based membranes:a pre-clinical minipig model

dc.contributor.author	Gómez, Juliana	es
dc.contributor.author	Bergamo, Edmara Tp	es
dc.contributor.author	Tovar, Nick	es
dc.contributor.author	Talib, Huzefa S	es
dc.contributor.author	Pippenger, Benjamin E.	es
dc.contributor.author	Herdia, Valeria	es
dc.contributor.author	Cox, Madison	es
dc.contributor.author	Coelho, Paulo G.	es
dc.contributor.author	Witek, Lukasz	es
dc.date.accessioned	2023-06-16T08:36:45Z
dc.date.available	2023-06-16T08:36:45Z
dc.date.issued	2021	es
dc.identifier.citation	Gomez, J., Bergamo, ET., Tovar, N., Talib, HS., Pippenger, BE., Herdia, V., Cox, M., Coelho, PG., & Witek, L. (2021). Microtomographic reconstruction of mandibular defects treated with xenografts and collagen-based membranes: A pre-clinical minipig model. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e825-e833). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24811	es
dc.identifier.uri	https://hdl.handle.net/10550/88092
dc.description.abstract	The goal of this study was to evaluate hard tissue response following guided bone regeneration using commercially available bovine bone grafts and collagen membranes; bilayer collagen membrane and porcine pericardium-based membrane, by means of a non-destructive three-dimensional (3D) computerized volumetric analysis following microtomography reconstruction. Bone regenerative properties of various bovine bone graft materials were evaluated in the Göttingen minipig model. Two standardized intraosseous defects (15mm x 8mm x 8mm) were created bilaterally of the mandible of eighteen animals (n=72 defects). Groups were nested within the same subject and randomly distributed among the sites: (i) negative control (no graft and membrane), (ii) bovine bone graft/bilayer collagen membrane (BOB) (iii) Bio-Oss® bone graft/porcine pericardium-based membrane (BOJ) and (iv) cerabone® bone graft/porcine pericardium-based membrane (CJ). Samples were harvested at 4, 8, and 12-week time points (n=6 animal/time point). Segments were scanned using computerized microtomography (?CT) and three dimensionally reconstructed utilizing volumetric reconstruction software. Statistical analyses were performed using IBM SPSS with a significance level of 5%. From a temporal perspective, tridimensional evaluation revealed gradual bone ingrowth with the presence of particulate bone grafts bridging the defect walls, and mandibular architecture preservation over time. Volumetric analysis demonstrated no significant difference between all groups at 4 weeks (p>0.127). At 8 and 12 weeks there was a higher percentage of new bone formation for control and CJ groups when compared to BOB and BOJ groups (p<0.039). The natural bovine bone graft group showed more potential for graft resorption over time relative to bovine bone graft, significantly different between 4 and 8 weeks (p<0.003). Volumetric analysis yielded a favorable mandible shape with respect to time through the beneficial balance between graft resorption/bone regenerative capacity for the natural bovine bone graft.	es
dc.subject	alcohol use disorder	es
dc.subject	healthcare students	es
dc.subject	addiction	es
dc.subject	health literacy	es
dc.subject	behaviours	es
dc.title	Microtomographic reconstruction of mandibular defects treated with xenografts and collagen-based membranes:a pre-clinical minipig model	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24811	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601645/