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Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction:a randomized, double-blind clinical trial

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Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction:a randomized, double-blind clinical trial

dc.contributor.author	Marques, Rogério Vera Cruz Ferro	es
dc.contributor.author	Branco de Almeida, Luciana S.	es
dc.contributor.author	Marques, Daniele Meira Conde	es
dc.contributor.author	de Oliveira, Izabel Cristina Vieira	es
dc.contributor.author	Mendes, Saulo José Figueiredo	es
dc.contributor.author	Rodrigues, Vandilson Pinheiro	es
dc.contributor.author	Lopes, Fernanda Ferreira	es
dc.date.accessioned	2023-06-16T08:36:45Z
dc.date.available	2023-06-16T08:36:45Z
dc.date.issued	2022	es
dc.identifier.citation	Marques, RV., Branco-de-Almeida, LS., Marques, DM., Oliveira, IC., Mendes, SJ., Rodrigues, VP., & Lopes, FF. (2022). Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction: a randomized, double-blind clinical trial. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e51-e58). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24894	es
dc.identifier.uri	https://hdl.handle.net/10550/88094
dc.description.abstract	To evaluate the efficacy of intra-alveolar administration of dexamethasone 4 mg in the control of edema, trismus, and pain resulting from the extraction of impacted lower third molars and the drug permeability through the oral mucosa by in silico prediction. The randomized, double-blind, split-mouth clinical trial included patients who had both impacted lower third molars in equivalent positions. Hemiarches were divided into control side when dexamethasone was administered orally and experimental side when dexamethasone was administered using the intra-alveolar route. Patients were evaluated considering edema, trismus, and pain. The permeability of dexamethasone through the oral mucosa was assessed by in silico prediction. Student?s t-test was selected for comparative analysis of edema and trismus, and the chi-square test analyzed the distribution of postoperative pain between the sides. There were no significant differences between the routes of administration in measuring symptoms between the pre and postoperative times (p>0.05). In silico prediction suggested that dexamethasone molecular characteristics facilitate intra-alveolar administration. Intra-alveolar administration had similar efficacy to oral administration in controlling symptoms of post-surgical inflammation of impacted lower third molars.	es
dc.subject	wisdom teeth	es
dc.subject	patient characteristics	es
dc.subject	radiological variables	es
dc.subject	surgeon experience	es
dc.subject	assessment form	es
dc.title	Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction:a randomized, double-blind clinical trial	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24894	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719784/