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Alterations of panoramic radiomorphometric indices in children and adolescents with beta-thalassemia major:a fractal analysis study

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Alterations of panoramic radiomorphometric indices in children and adolescents with beta-thalassemia major:a fractal analysis study

dc.contributor.author	Yagmur, Burcu	es
dc.contributor.author	Tercanli-Alkis, Humeyra	es
dc.contributor.author	Tayfun-Kupesiz, Funda	es
dc.contributor.author	Karayilmaz, Hüseyin	es
dc.contributor.author	Küpesiz, Alphan	es
dc.date.accessioned	2023-06-16T08:36:46Z
dc.date.available	2023-06-16T08:36:46Z
dc.date.issued	2022	es
dc.identifier.citation	Yagmur, B., Tercanli-Alkis, H., Tayfun-Kupesiz, F., Karayilmaz, H., & Kupesiz, OA. (2022). Alterations of panoramic radiomorphometric indices in children and adolescents with beta-thalassemia major: A fractal analysis study. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e10-e17). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24784	es
dc.identifier.uri	https://hdl.handle.net/10550/88102
dc.description.abstract	Beta-thalassemia major is an inherited disorder that can cause bone deformity and loss of bone mineral density. The objective of this study is to evaluate the cortical and trabecular mandibular bone morphology of children and adolescents who have beta-thalassemia major (ß-TM) using a fractal dimension (FD) analysis and different panoramic radiomorphometric indices with digital panoramic radiographic images (DPRIs). The study included 80 patients (with 40 patients each of ß-TM and control). The mandibular cortical width (MCW), panoramic mandibular index (PMI), mandibular cortical index (MCI), and simple visual estimation (SVE) were evaluated, and an FD analysis of five regions of interest (ROIs) (ROI 1: in basal cortical bone; ROI 2: in premolar region; ROI 3: in molar region; ROI 4: in angulus mandible and ROI 5: in condyle region) was obtained in all DPRIs. Quantitative variables were analyzed using the student?s t-test , Kruskal?Wallis and Mann-Whitney U tests. When the ß-TM groups were compared with controls, there were no statistically significant differences found in the mean FD values, the ROIs of the trabecular bone, or the SVE. There was a significant correlation in the mean MCW, PMI, ROI of cortical bone (ROI 1), and MCI between ß-TM and control groups (p < 0.001, p < 0.001, p = 0.047, and p = 0.046, respectively). The mean MCW values correlated with the SVE in both the ß-TM and control groups (p = 0.031 and p < 0.001, respectively). While the mean MCW values correlated with the MCI (p = 0.04) in the control group, the mean MCW values were not correlated with the MCI (p = 0.493) in ß-TM group. The current study revealed lower MCW and PMI values in the ß-TM group. While the mean FD values of trabecular bone is similar to the control groups, the mean FD value is lower in cortical bone in the ß-TM group. MCW, PMI, FD of cortical bone and MCI may be key indicators in individuals with beta-thalassemia major.	es
dc.subject	mirnas	es
dc.subject	oral leukoplakia	es
dc.subject	oral squamous cell carcinoma	es
dc.subject	biomarkers	es
dc.subject	malignant transformation	es
dc.title	Alterations of panoramic radiomorphometric indices in children and adolescents with beta-thalassemia major:a fractal analysis study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24784	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719792/