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MicroRNAs and their role in the malignant transformation of oral leukoplakia:a scoping review

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MicroRNAs and their role in the malignant transformation of oral leukoplakia:a scoping review

dc.contributor.author	Niklander, Sven	es
dc.contributor.author	Guerra, Daniela	es
dc.contributor.author	Contreras, Felipe	es
dc.contributor.author	González-Arriagada, Wilfredo	es
dc.contributor.author	Marín, Constanza	es
dc.date.accessioned	2023-06-16T08:36:46Z
dc.date.available	2023-06-16T08:36:46Z
dc.date.issued	2022	es
dc.identifier.citation	Niklander, S., Guerra, D., Contreras, F., González-Arriagada, W., & Marín, C. (2022). MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e77-e84). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24975	es
dc.identifier.uri	https://hdl.handle.net/10550/88103
dc.description.abstract	MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. We conducted a systematic search with the following MeSH terms: ?oral leukoplakia?, ?carcinoma in situ?, ?microRNAs?, ?mouth neoplasms? and ?epithelial?mesenchymal transition? in PubMed/MEDLINE, EMBASE and SpringerLink. Fifteen articles were included for analysis, among which in vivo and in vitro articles were included. A total of 21 different miRNAs were found to be involved in the malignant transformation process of oral leukoplakia. Regarding their possible effects, 6 miRNAs were classified as oncogenic, 5 as tumour suppressors and 10 were related to epithelial?mesenchymal transition, invasion and migration. Based on the current review, we concluded that miRNAs-21, 345, 181-b and 31* seem to be potential markers of malignant transformation of oral leukoplakia. However, further clinical prospective studies are needed in order to validate their utility as prognostic biomarkers.	es
dc.subject	salivary gland calculi	es
dc.subject	cone-beam computed tomography	es
dc.subject	observer variation	es
dc.title	MicroRNAs and their role in the malignant transformation of oral leukoplakia:a scoping review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24975	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719793/