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Prognostic importance of DNA from human papillomavirus in patients with oral squamous cell carcinoma

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Prognostic importance of DNA from human papillomavirus in patients with oral squamous cell carcinoma

dc.contributor.author	Perez, Elizabeth	es
dc.contributor.author	García Carrancá, Alejandro	es
dc.contributor.author	Acosta Gío, Enrique	es
dc.contributor.author	Reynoso Noverón, Nancy	es
dc.contributor.author	Maldonado Martínez, Héctor A.	es
dc.contributor.author	Guido-Jiménez, Miriam	es
dc.contributor.author	Sobrevilla-Moreno, Nora	es
dc.contributor.author	Granados García, Martín	es
dc.contributor.author	Pérez-Báez, Wendy B	es
dc.contributor.author	Vilar Compte, Diana	es
dc.date.accessioned	2023-06-16T08:36:47Z
dc.date.available	2023-06-16T08:36:47Z
dc.date.issued	2022	es
dc.identifier.citation	Pérez-Islas, E., García-Carrancá, A., Acosta-Gio, E., Reynoso-Noverón, N., Maldonado-Martínez, HA., Guido-Jiménez, M., Sobrevilla-Moreno, N., Granados-García, M., Pérez-Báez, WB., & Vilar-Compte, D. (2022). Prognostic importance of DNA from human papillomavirus in patients with oral squamous cell carcinoma. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e150-e158). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25092	es
dc.identifier.uri	https://hdl.handle.net/10550/88111
dc.description.abstract	Survival of patients with oral squamous cell carcinoma (OSCC) is generally low, with the likelihood of locoregional recurrence or disease progression (LR/DP). Knowledge of prognostic factors for survival is key to achieving an understanding and increased survival. The present study aimed to identify prognostic factors for patients with OSCC, especially the presence of DNA from human papillomavirus (HPV). Retrospective cohort study including 119 patients with OSCC treated at the National Cancer Institute in Mexico City (2009-2013). Clinical information was obtained from patient records including LR/DP. Formalin-fixed, paraffin-embedded tissues were obtained and used for detecting DNA from different types of HPV. Potential prognostic factors for Overall Survival (OS) were analyzed using the Cox proportional hazards model. After model adjustment, factors associated with longer OS were a pre-treatment platelet count above 400,000/mm3 (HR=0.09, p=0.026) and response to primary treatment (HR=0.26, p=0.001). HPV DNA was present in 23 (19.3%) of the patients and importantly, type 16 found in 19 of them. Although survival of HPV-positive patients was longer, difference was not significant. However, among patients with LR/DP, HPV positivity was significantly associated with increased survival (HR=0.23, p=0.034). Importantly, survival was significantly different for HPV-positive patients with LR/DP > 6 months (HR=0.20, p=0.002), had higher absolute lymphocyte count at start of treatment (HR=0.50, p=0.028) or had local rescue treatment (HR=0.24, p=0.019). Although HPV positivity was not associated with a longer OS of OSCC patients, a better prognosis was significantly associated with HPV positivity and recurring or progressing disease, particularly with HPV type 16.	es
dc.subject	condylar asymmetry	es
dc.subject	ramal asymmetry	es
dc.subject	odontogenic cysts	es
dc.title	Prognostic importance of DNA from human papillomavirus in patients with oral squamous cell carcinoma	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25092	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898585/