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Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

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Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

dc.contributor.author	Grossi, João Ricardo Almeida	es
dc.contributor.author	Parra, Marcelo	es
dc.contributor.author	Benalcázar-Jalkh, Ernesto B	es
dc.contributor.author	Giovanini, Allan Fernando	es
dc.contributor.author	Zielak, João Cézar	es
dc.contributor.author	Sebstiani, Aline Monise	es
dc.contributor.author	Gonzaga, Carla Castiglia	es
dc.contributor.author	Coelho, Paulo G.	es
dc.contributor.author	Witek, Lukasz	es
dc.contributor.author	Deliberador, Tatiana Miranda	es
dc.date.accessioned	2023-06-16T08:36:47Z
dc.date.available	2023-06-16T08:36:47Z
dc.date.issued	2022	es
dc.identifier.citation	Grossi, JR., Parra, M., Benalcázar-Jalkh, EB., Giovanini, AF., Zielak, JC., Sebstiani, AM., Gonzaga, CC., Coelho, PG., Witek, L., & Deliberador, TM. (2022). Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e174-e180). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25164	es
dc.identifier.uri	https://hdl.handle.net/10550/88114
dc.description.abstract	The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant?s surface at the early stages of osseointegration. Sixty tapered acid-etched titanium implants were divided into four groups: i) Collagen, used as a control group; and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations: ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6- and 12-weeks of healing samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Statistical analysis as a function of time in vivo and coating resulted in no significant differences for BIC and BAFO at any evaluation time point. Histological evaluation demonstrated similar osseointegration features for all groups with woven bone formation at 3 weeks and progressive replacement of woven for lamellar bone in close contact with the implant surface and within the implant?s threads. A single local application of growth hormone to the surface of titanium implants did not yield improved implant osseointegration independent of healing time.	es
dc.subject	onlay graft	es
dc.subject	cortical graft	es
dc.subject	intraoral bone	es
dc.subject	augmentation procedure	es
dc.title	Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25164	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898577/