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Is immunohistochemistry more sensitive than hematoxylin-eosin staining for identifying perineural or lymphovascular invasion in oral squamous cell carcinoma? A systematic review and meta-analysis

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Is immunohistochemistry more sensitive than hematoxylin-eosin staining for identifying perineural or lymphovascular invasion in oral squamous cell carcinoma? A systematic review and meta-analysis

dc.contributor.author	Negreiros Nunes Alves, Ana Paula	es
dc.contributor.author	de Paula, Dayrine Silveira	es
dc.contributor.author	Lima, Lia Vila Real	es
dc.contributor.author	Sousa-Dantas, Thinali	es
dc.contributor.author	Lima Mota, Mário Rogério	es
dc.contributor.author	Sousa, Fabrício Bitu	es
dc.contributor.author	Silva, Paulo-Goberlânio-de Barros	es
dc.date.accessioned	2023-06-16T08:36:48Z
dc.date.available	2023-06-16T08:36:48Z
dc.date.issued	2022	es
dc.identifier.citation	Alves, AP., Paula, DS., Lima, LV., Dantas, TS., Mota, MR., Sousa, FB., & Silva, PG. (2022). Is immunohistochemistry more sensitive than hematoxylin-eosin staining for identifying perineural or lymphovascular invasion in oral squamous cell carcinoma? A systematic review and meta-analysis. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e238-e247). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25114	es
dc.identifier.uri	https://hdl.handle.net/10550/88122
dc.description.abstract	This study aimed to analyze whether immunohistochemistry (IHC) is more sensitive than hematoxylin-eosin (H&E) staining for identifying perineural invasion (PNI) or lymphovascular invasion (LVI) in oral squamous cell carcinoma (OSCC). In this systematic review and meta-analysis (Prospective Register of Systematic Reviews ? CRD 42021256515), data were obtained from six databases (PubMed, Scopus, LILACS, Web of Science, EBSCO, LIVIVO, Embase) and the grey literature. Cross-sectional observational studies of the diagnostic sensitivity of IHC for PNI and LVI were included. Studies were selected in two phases: first collection and reference retrieval. The Quality Assessment of Diagnostic Accuracy Studies-2 tool assessed study quality, while the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach assessed evidence quality. The meta-analysis (random effects model) was performed using MedCalc 18.2.1 software (MedCalc®) (p<0.05). Four studies (560 patients with 295 biopsies) were analyzed. The combined sensitivity was 76% (95% confidence interval [CI], 44.30?97.19%) and specificity was 42% (95% CI, 23.40?62.02%). The positive predictive value (PPV) and negative predictive value (NPV) were 61% (95% CI, 49.78?71.53%) and 70% (95% CI, 37.63?94.43%). The overall accuracy was 58% (95% CI, 45.17?70.65%). The risk of bias was low, and GRADE analysis showed a very low certainty of evidence. Our data suggest that IHC staining to highlight PNI/LVI may be useful in cases in which H&E analysis results in a negative decrease in the prevalence of false-negative cases and underestimated treatment.	es
dc.subject	stomatitis	es
dc.subject	antineoplastic agents	es
dc.subject	neoplasms	es
dc.subject	microbiota	es
dc.subject	immunotherapy	es
dc.title	Is immunohistochemistry more sensitive than hematoxylin-eosin staining for identifying perineural or lymphovascular invasion in oral squamous cell carcinoma? A systematic review and meta-analysis	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25114	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054170/