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Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population

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Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population

dc.contributor.author	Louredo, Brendo Vinícius Rodrigues	es
dc.contributor.author	Vargas, Pablo Agustín	es
dc.contributor.author	Pérez-de-Oliveira, Maria Eduarda	es
dc.contributor.author	Lopes, Márcio Ajudarte	es
dc.contributor.author	Kowalski, Luiz Paulo	es
dc.contributor.author	Curado, María Paula	es
dc.date.accessioned	2023-06-16T08:36:48Z
dc.date.available	2023-06-16T08:36:48Z
dc.date.issued	2022	es
dc.identifier.citation	Louredo, BV., Vargas, PA., Pérez-de-Oliveira, ME., Lopes, MA., Kowalski, LP., & Curado, MP. (2022). Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e274-e284). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25147	es
dc.identifier.uri	https://hdl.handle.net/10550/88126
dc.description.abstract	Lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC) represent a major health problem in the global scenario. In South America, the highest incidence rates are seen in Brazil. Therefore, the epidemiological and clinical profile and survival outcomes of lip, oral cavity, and oropharyngeal SCC was studied in São Paulo State, Brazil. The clinicopathological data of 12,099 patients with lip, oral cavity, and oropharyngeal SCC were obtained from hospital cancer registries of the Fundação Oncocentro de São Paulo, Brazil (2010?2015). Survival rates and other analyses were performed using SPSS software. A clear male predominance was observed, particularly for patients with oropharyngeal SCC (88.3%). The average age of patients was higher for lip cases (65 ± 13.5 years) compared to other sites. The schooling level was low for most patients, especially in lip cases (87.9%). Most of the patients with oral cavity (71.8%) and oropharyngeal (86.3%) SCC had advanced-stage (III?IV) disease. However, the majority of lip cases (83.3%) were at an early stage (I?II). Surgical excision was the main treatment for lip (72%) and oral cavity SCC (23.5%), and chemoradiotherapy was the main treatment for oropharyngeal SCC (40.2%). The 5-year overall survival (OS) for patients with lip, oral cavity, and oropharyngeal SCC were 66.3, 30.9, and 22.6%, respectively. Multivariate analysis revealed that the determinants of OS were different for lip, oral cavity, and oropharyngeal SCC, except for those at the clinical stage, which was an independent predictor for all sites. OS-independent determinants varied according to the affected site. Oral cavity and oropharyngeal SCC presented worse survival rates than those for lip SCC.	es
dc.subject	head and neck	es
dc.subject	cancer	es
dc.subject	children	es
dc.subject	adolescent	es
dc.subject	signs	es
dc.subject	symptoms	es
dc.title	Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25147	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054163/