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Clinical manifestations of head and neck cancer in pediatric patients, an analysis of 253 cases in a single Brazilian center

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Clinical manifestations of head and neck cancer in pediatric patients, an analysis of 253 cases in a single Brazilian center

dc.contributor.author	Arboleda, Lady Paola Aristizábal	es
dc.contributor.author	Pérez-de-Oliveira, Maria Eduarda	es
dc.contributor.author	Hoffmann, Iva Loureiro	es
dc.contributor.author	Cardinalli, Izilda Aparecida	es
dc.contributor.author	Gallagher, Karen Patricia Dominguez	es
dc.contributor.author	Santos Silva, Alan Roger	es
dc.contributor.author	de Mendonça, Regina Maria Holanda	es
dc.date.accessioned	2023-06-16T08:36:48Z
dc.date.available	2023-06-16T08:36:48Z
dc.date.issued	2022	es
dc.identifier.citation	Arboleda, LP., Pérez-de-Oliveira, ME., Hoffmann, IL., Cardinalli, IA., Gallagher, KP., Santos-Silva, AR., & Mendonça, RM. (2022). Clinical manifestations of head and neck cancer in pediatric patients, an analysis of 253 cases in a single Brazilian center. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e285-e293). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25255	es
dc.identifier.uri	https://hdl.handle.net/10550/88127
dc.description.abstract	Pediatric head and neck cancer (PHNC) is rare and its nonspecific clinical manifestations may often lead to delayed diagnosis. We aimed to describe the signs, symptoms, and clinicopathological characteristics of PHNC. Medical records were retrospectively reviewed for all PHNC cases diagnosed from 1986 to 2016 affecting patients aged 19-years and younger from a tertiary referral center in Brazil. Demographic variables, anatomical site of primary tumors, histopathological diagnoses, signs and symptoms, and patterns of misdiagnosis were collected and interpreted by statistical and descriptive analysis. A total of 253 PHNC cases were included. The mean age was 9.3 years and male patients were more frequently affected (60.9%). Burkitt lymphoma (23.7%), nasopharyngeal carcinoma (15.8%), and rhabdomyosarcoma (15.4%) were the most common cancer types. The nasopharynx (28.9%), cervical/lymph node region (25.3%), and craniofacial bones (8.3%) were the predominant anatomical sites. Tumor/swelling (68.4%), was the clinical finding often presented. The univariable analysis showed association between tumor histology and clinical variables such as sex (p=0.022), age (p<0.0001), anatomical location (p<0.0001) tumor/swelling (p=0.034), pain (p=0.031), systemic/general manifestations (p=0.004), nasal/breathing alterations (p=0.012), orbital/ocular alterations (p<0.0001). Misdiagnosis such as tonsillitis, otitis, and abscess were frequent. Although the clinical findings of PHNC are often unspecific, this study provided signs and symptoms with significant correlations between tumor histology. The suspicion of malignancy should be considered when the main signs and symptoms reported here appear and persist, in order to conduct a timely diagnosis.	es
dc.subject	informed consent	es
dc.subject	legality of informed consent	es
dc.subject	principle of autonomy	es
dc.subject	defensive medicine	es
dc.subject	satisfactive medicine	es
dc.subject	health law	es
dc.subject	stomatology	es
dc.subject	oral surgery	es
dc.subject	dentistry	es
dc.title	Clinical manifestations of head and neck cancer in pediatric patients, an analysis of 253 cases in a single Brazilian center	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25255	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054174/