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Prognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma:a systematic review

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Prognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma:a systematic review

dc.contributor.author	de Morais, Everton Freitas	es
dc.contributor.author	Morais, Hannah Gil de Farias	es
dc.contributor.author	Martins, Hélder-Domiciano-Dantas	es
dc.contributor.author	Carlan, Leonardo Magalhães	es
dc.contributor.author	Costa, Antônio de Lisboa Lopes	es
dc.contributor.author	Freitas, Roseana A.	es
dc.date.accessioned	2023-06-16T08:36:49Z
dc.date.available	2023-06-16T08:36:49Z
dc.date.issued	2022	es
dc.identifier.citation	Morais, EF., Morais, HG., Martins, HD., Carlan, LM., Costa, Ad., & Freitas, Rd. (2022). Prognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma: A systematic review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e301-e309). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24922	es
dc.identifier.uri	https://hdl.handle.net/10550/88129
dc.description.abstract	Analysis of the tumor microenvironment has been proposed as a strategy for the treatment and prognosis of different neoplastic processes. A grading system based on the tumor-stroma ratio (TSR), which evaluates the proportion of stroma in relation to neoplastic parenchyma at the invasion front, has shown a strong prognostic value in different neoplastic processes. The aim of the present systematic review was to understand the role of the TSR in head and neck squamous cell carcinoma (HNSCC), evaluating its correlation with clinical and prognostic parameters. An electronic search was performed in PubMed/Medline, Web of Science, Science Direct, Scopus, Embase, and the Cochrane Collaboration Library. Publications assessing the relationship between TSR and prognosis in cases of HNSCC were eligible. The quality of the studies was assessed independently by four evaluators using the Newcastle-Ottawa scale. After application of the previously es+lished inclusion/exclusion criteria, nine articles were included in the qualitative synthesis. With regards to quality on the Newcastle-Ottawa scale, an overall value of 4.55 was obtained. This systematic review demonstrated a strong association between TSR and prognosis in esophageal and oral squamous cell carcinomas. Histopathological analysis of the TSR can optimize the analysis of the prognosis of cases diagnosed with HNSSC. In addition, the TSR is a reliable and simple parameter that can be evaluated in hematoxylin/eosin-stained slides during routine laboratory examinations, showing high inter- and intraobserver agreement.	es
dc.subject	actinic cheilitis	es
dc.subject	solar cheilosis	es
dc.subject	lip	es
dc.subject	precancerous conditions	es
dc.subject	oral diagnosis	es
dc.subject	epitelial dysplasia	es
dc.title	Prognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma:a systematic review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.24922	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271351/