NAGIOS: RODERIC FUNCIONANDO

Bone regeneration at extraction sockets filled with leukocyte-platelet-rich fibrin:an experimental pre-clinical study

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Bone regeneration at extraction sockets filled with leukocyte-platelet-rich fibrin:an experimental pre-clinical study

dc.contributor.author	Park, Gene	es
dc.contributor.author	Benalcázar-Jalkh, Ernesto B	es
dc.contributor.author	Boczar, Daniel	es
dc.contributor.author	Bergamo, Edmara Tp	es
dc.contributor.author	Kim, Heoijin	es
dc.contributor.author	Kurgansky, Gregory	es
dc.contributor.author	Torroni, Andrea	es
dc.contributor.author	Gil, Luiz	es
dc.contributor.author	Bonfante, Estevam A.	es
dc.contributor.author	Coelho, Paulo G.	es
dc.contributor.author	Witek, Lukasz	es
dc.date.accessioned	2023-06-16T08:36:50Z
dc.date.available	2023-06-16T08:36:50Z
dc.date.issued	2022	es
dc.identifier.citation	Park, G., Jalkh, EB., Boczar, D., Bergamo, ET., Kim, H., Kurgansky, G., Torroni, A., Gil, LF., Bonfante, EA., Coelho, PG., & Witek, PG. (2022). Bone regeneration at extraction sockets filled with leukocyte-platelet-rich fibrin: An experimental pre-clinical study. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e468-e475). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25462	es
dc.identifier.uri	https://hdl.handle.net/10550/88145
dc.description.abstract	We aimed to histomorphometrically evaluate the effects of Leucocyte-Platelet-Rich Fibrin (L-PRF), with and without the combination of a bone grafting material, for alveolar ridge preservation using an in vivo canine model. Seven dogs (Female Beagles, ~18-month-old) were acquired for the study. L-PRF was prepared from each individual animal by drawing venous blood and spinning them through a centrifuge at 408 RCF-clot (IntrasSpin, Intra-Lock, Boca Raton, FL). L-PRF membranes were obtained from XPression fabrication kit (Biohorizons Implant Systems, Inc., AL, USA). A split mouth approach was adopted with the first molar mesial and distal socket defects treated in an interpolated fashion of the following study groups: 1) Empty socket (negative control); 2) OSS filled defect 3) L-PRF membrane; and 4) Mix of Bio-Oss® with L-PRF. After six weeks, samples were harvested, histologically processed, and evaluated for bone area fraction occupancy (BAFO), vertical/horizontal ridge dimensions (VRD and HRD, respectively), and area of coronal soft tissue infiltration. BAFO was statistically lower for the control group in comparison to all treatment groups. Defects treated with Bio-Oss® were not statistically different then defects treated solely with L-PRF. Collapsed across all groups, L-PRF exhibited higher degrees of BAFO than groups without L-PRF. Defects filled with Bio-Oss® and Bio-Oss® with L-PRF demonstrated greater maintenance of VRD relative to the control group. Collapsed across all groups, Bio-Oss® maintained the VRD and resulted in less area of coronal soft tissue infiltration compared to the empty defect. Soft tissue infiltration observed at the coronal area was not statistically different among defects filled with L-PRF, Bio-Oss®, and Bio-Oss® with L-PRF. Inclusion of L-PRF to particulate xenograft did not promote additional bone heading at 6 weeks in vivo. However, we noted that L-PRF alone promoted alveolar socket regeneration to levels comparable to particulate xenografts, suggesting its potential utilization for socket preservation.	es
dc.subject	mouth neoplasms	es
dc.subject	oral diagnosis	es
dc.subject	health service coverage	es
dc.title	Bone regeneration at extraction sockets filled with leukocyte-platelet-rich fibrin:an experimental pre-clinical study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25462	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445612/