NAGIOS: RODERIC FUNCIONANDO

Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions

dc.contributor.author	Hassaf-Arreola, Alina Gabriela	es
dc.contributor.author	Caro-Sánchez, Claudia Haydee S	es
dc.contributor.author	Domínguez Malagón, Hugo	es
dc.contributor.author	Irigoyen Camacho, María Esther	es
dc.contributor.author	Almeida, Oslei Paes de	es
dc.contributor.author	Sánchez-Romero, Celeste	es
dc.contributor.author	Mosqueda Taylor, Adalberto	es
dc.date.accessioned	2023-06-16T08:36:51Z
dc.date.available	2023-06-16T08:36:51Z
dc.date.issued	2022	es
dc.identifier.citation	Hassaf-Arreola, AG., Caro-Sánchez, CH., Domínguez-Malagón, H., Irigoyen-Camacho, ME., Almeida, OP., Sánchez-Romero, C., & Mosqueda-Taylor, A. (2022). Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e497-e506). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25326	es
dc.identifier.uri	https://hdl.handle.net/10550/88155
dc.description.abstract	Myofibroblasts (MF) are mesenchymal cells with features of both fibroblasts and smooth muscle cells. Although these are usually reactive cells, they can lead to myofibroblastic tumors that may share clinical and histomorphological characteristics but with different prognosis. The aim of this study is to perform a histomorphological evaluation as well as to compare and evaluate two different cell proliferation immunomarkers and two endothelial markers in a group of oral and maxillofacial myofibroblastic lesions (MFL). Cross-sectional and retrospective study. Demographic, clinical, histomorphological and immunohistochemical characteristics of 39 cases of MFL were analyzed. Immunohistochemical reactions were performed with the Ki67, MCM2, CD34 and CD105 antibodies. Kruskal-Wallis test and Spearman correlation analysis were used. Four cases of nodular fasciitis (NF), 18 myofibromas (My), 6 desmoplastic fibromas (DF), 7 inflammatory myofibroblastic tumors (IMT) and 4 myofibroblastic sarcomas (MFS) were studied. There were twenty women (51.2%); the median age was 13 [Q1-Q3: 8-24] years and most cases occurred in the mandible (48.7%). A statistically significant difference with MCM2 immunostaining (p=0.0221) was observed between the MFL; furthermore, a correlation between CD34 and CD105 immunostaining in NF (p <0.0001) and IMT (p=0.0408), between MCM2 and CD34 in IMT (p=0.0362) and between MCM2 and CD105 in MFS (p <0001) were found. MCM2 immunostaining could assess more clearly the cell growth fraction in MFL. The correlation between MCM2 and CD34 in IMT and between MCM2 and CD105 in MFS are indicative of the high activity of these lesions. These results emphasize the importance of the studied immunohistochemistry markers as possible tools for a better characterization of some of the MFL.	es
dc.subject	orthognathic surgery	es
dc.subject	systematic review	es
dc.subject	virtual planning	es
dc.title	Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25326	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648641/