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Is the injection of tramadol effective at control of pain after impacted mandibular third molar extractions? A systematic review and meta-analysis

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Is the injection of tramadol effective at control of pain after impacted mandibular third molar extractions? A systematic review and meta-analysis

dc.contributor.author	Gonçalves, Kalyne Kelly Negromonte	es
dc.contributor.author	dos Santos, Marcelo Soares	es
dc.contributor.author	Barbirato, Davi da Silva	es
dc.contributor.author	Silva, Caio César Gonçalves	es
dc.contributor.author	Martins-de-Barros, Allan Vinícius	es
dc.contributor.author	de Araújo, Emerllyn Shayane Martins	es
dc.contributor.author	Almeida, Renata de Albuquerque Cavalcanti	es
dc.contributor.author	Cavalcanti do Egito Vasconcelos, Belmiro	es
dc.date.accessioned	2023-06-16T08:36:52Z
dc.date.available	2023-06-16T08:36:52Z
dc.date.issued	2022	es
dc.identifier.citation	Gonçalves, KK., Santos, MS., Barbirato, Dd., Silva, CC., Barros, AV., Araújo, ES., Almeida, Rd., & Vasconcelos, BC. (2022). Is the injection of tramadol effective at control of pain after impacted mandibular third molar extractions? A systematic review and meta-analysis. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e560-e568). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25498	es
dc.identifier.uri	https://hdl.handle.net/10550/88162
dc.description.abstract	Third molar extraction is among the most common surgical procedures performed by oral-maxillofacial surgeons. Postoperative pain, swelling and trismus are common, especially in wisdom teeth, due to trauma to local tissues and the duration of the surgical procedure, among other factors. This systematic review was conducted in accordance with the ?Preferred Reporting Items for Systematic Reviews and Meta-Analyses? in order to answer the focused question: ?Is the local submucosal injection of tramadol effective at the control of postoperative pain in patients submitted to impacted mandibular third molar extractions??. We analyzed papers published until March 30, 2021 in the MEDLINE\|PubMed, Web of Science and Cochrane Library databases. Gray literature was also consulted. Standard pairwise meta-analyses of direct comparisons were performed using a fixed-effect model; I2 ? 50 % or ? 75 % indicated moderate or high heterogeneity, respectively. Risk of bias was assessed by Cochrane Collaboration?s tool. In total, 172 participants (98 males and 74 females, aged 18 or over) from three randomized placebo-controlled trials were considered for analysis. The submucosal injection of 2 ml of tramadol adjacent to the impacted mandibular third molar was effective in controlling pain up to 6-hours after surgery, in increasing the onset of consumption of rescue analgesic and in reducing the total number of rescue analgesics used. The submucosal injection of tramadol can be considered a safe and effective procedure for pain control after impacted mandibular third molar extractions.	es
dc.subject	pediatric	es
dc.subject	rhabdomyosarcoma	es
dc.subject	head and neck	es
dc.subject	histologic	es
dc.subject	immunohistochemistry	es
dc.title	Is the injection of tramadol effective at control of pain after impacted mandibular third molar extractions? A systematic review and meta-analysis	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25498	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648643/