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Clinical characteristics of oral chronic graft-versus-host disease according to the 2014 National Institutes of Health (USA) consensus criteria

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Clinical characteristics of oral chronic graft-versus-host disease according to the 2014 National Institutes of Health (USA) consensus criteria

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dc.contributor.author Pengpis, Nawaporn es
dc.contributor.author Prueksrisakul, Titipong es
dc.contributor.author Chanswangphuwana, Chantiya es
dc.date.accessioned 2023-06-16T08:36:54Z
dc.date.available 2023-06-16T08:36:54Z
dc.date.issued 2023 es
dc.identifier.citation Pengpis, N., Prueksrisakul, T., & Chanswangphuwana, C. (2023). Clinical characteristics of oral chronic graft-versus-host disease according to the 2014 National Institutes of Health (USA) consensus criteria. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e167-e173). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25629 es
dc.identifier.uri https://hdl.handle.net/10550/88187
dc.description.abstract Chronic graft-versus-host disease (cGVHD) is a serious and common complication of allogeneic hematopoietic cell transplantation (alloHCT). The oral cavity is the second most common site affected by cGVHD. In 2014, the 2005 National Institutes of Health (NIH) consensus criteria were revised to address areas of controversy. The aim of this study was to evaluate the clinical characteristics of oral cGVHD using the 2014 NIH consensus criteria. The baseline data of oral manifestation of patients, who were diagnosed with oral cGVHD, in the first dental visit were analyzed (n=22). The oral mucosal disease was evaluated by NIH modified Oral Mucosa Rating Scale (OMRS) and Thongprasom sign score. The salivary gland disease and sclerotic disease were determined by the presence of signs and symptoms. The functional impact was assessed by the organ-specific severity score. The median time from transplant to oral cGVHD diagnosis was 11.9 months. White striae with an erosive area was found in 72.7% of the patients. The mean ± SD of NIH modified OMRS was 6.1 ± 3.0. The most common and severely affected site of lichen planus-like features was buccal mucosa. Xerostomia, superficial mucocele and limited mouth opening were found in 18.2%, 9.1%, and 9.1%, respectively, of the patients. Almost all patients (90.9%) had partial limitation of oral intake. There were no significant differences in NIH modified OMRS or organ-specific severity score among the patient characteristic groups. Moreover, there was no association between the oral manifestations of cGVHD and the patient characteristics. The most common oral manifestation of cGVHD was white striae with an erosive area of oral mucosal disease, followed by xerostomia, superficial mucocele, and limited mouth opening. The 2014 NIH consensus criteria for diagnostic and severity assessment are informative and feasible in real-world practice. es
dc.subject oral squamous cell carcinoma es
dc.subject tumor budding es
dc.subject microvascular density es
dc.title Clinical characteristics of oral chronic graft-versus-host disease according to the 2014 National Institutes of Health (USA) consensus criteria es
dc.type journal article es_ES
dc.subject.unesco UNESCO:CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.25629 es
dc.type.hasVersion VoR es_ES
dc.identifier.url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985937/

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