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Microvascular density and tumor budding in oral squamous cell carcinoma

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Microvascular density and tumor budding in oral squamous cell carcinoma

dc.contributor.author	Assis, Eliene Magda de	es
dc.contributor.author	Rodrigues, Mayara	es
dc.contributor.author	Vieira, Jéssica Campos	es
dc.contributor.author	Pascoaloti, Maria Inês Mantuani	es
dc.contributor.author	Júnior, Helvécio Marangon	es
dc.contributor.author	Souto, Giovanna Ribeiro	es
dc.contributor.author	Souza, Paulo Eduardo Alencar	es
dc.contributor.author	Horta, Martinho Campolina Rebello	es
dc.date.accessioned	2023-06-16T08:36:54Z
dc.date.available	2023-06-16T08:36:54Z
dc.date.issued	2023	es
dc.identifier.citation	Assis, EM., Rodrigues, M., Vieira, JC., Pascoaloti, MI., Júnior, HM., Souto, GR., Souza, PE., & Horta, MC. (2023). Microvascular density and tumor budding in oral squamous cell carcinoma. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e174-e182). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25640	es
dc.identifier.uri	https://hdl.handle.net/10550/88188
dc.description.abstract	Oral squamous cell carcinoma (OSCC) is the most prevalent malignant head and neck tumor, excluding the nonmelanoma skin cancer. Despite recent advances in the diagnosis and treatment, the disease's mortality rate is nonetheless high. The presence of isolated neoplastic cells or small clusters of up to four cells at the tumor?s invasive front, named tumor budding, is associated with a worse prognosis in OSCC. Angiogenesis has also been recognized as a determining factor in the progression of malignancies and in the development of metastases. Several studies have investigated the assessment of microvascular density (MVD) as a potential prognostic factor in OSCC. This study aimed to evaluate, in OSCC, differences in MVD between tumors with high-intensity tumor budding and tumors with low-intensity or no tumor budding. In samples with high-intensity tumor budding, differences in MVD between the budding area and the area outside the budding were also evaluated. Moreover, the study assessed differences in MVD concerning clinicopathological characteristics such as sex, age, tobacco smoking, tumor location and tumor size. One hundred and fifty [150] samples of OSCC were subjected to immunohistochemistry to assess the intensity of tumor budding (by immunostaining for multi-cytokeratin) and MVD (by immunostaining for CD34 and CD105, independently). The data were treated using descriptive and analytical statistics. There were no differences in MVD, assessed by immunostaining for CD34 or CD105, concerning clinicopathological characteristics such as sex, age, tobacco smoking, tumor location and tumor size (p > 0.05). Tumors with high-intensity tumor budding did not show differences in MVD, assessed by immunostaining for CD34 or CD105, when compared to tumors with low-intensity or no tumor budding (p > 0.05). However, in samples with high-intensity tumor budding, the MVD assessed by immunostaining for CD34 was higher in the budding area than in the area outside the budding (p < 0.05). This difference was not observed when MVD was assessed by immunostaining for CD105 (p > 0.05). The higher MVD in the budding area may be an additional indication that this is a peculiar region of the tumor, associated with biological phenomena related to tumor progression.	es
dc.subject	decellularized allograft	es
dc.subject	alveolar inferior nerve	es
dc.subject	allograft	es
dc.subject	injury	es
dc.title	Microvascular density and tumor budding in oral squamous cell carcinoma	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25640	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985932/