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Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects:a systematic review

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Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects:a systematic review

dc.contributor.author	Matus, Gustavo	es
dc.contributor.author	Aravena, Juan Pablo	es
dc.contributor.author	Mariño, Dylan	es
dc.contributor.author	Niklander, Sven	es
dc.date.accessioned	2023-06-16T08:36:54Z
dc.date.available	2023-06-16T08:36:54Z
dc.date.issued	2023	es
dc.identifier.citation	Matus, G., Aravena, JP., Mariño, D., & Niklander, SE. (2023). Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects: a systematic review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e183-e190). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25647	es
dc.identifier.uri	https://hdl.handle.net/10550/88189
dc.description.abstract	Inferior alveolar nerve (IAN) injuries are a clinical problem with devastating consequences, causing temporary or permanent paresthesia, significantly affecting the patient's quality of life. Despite morbidity, side effects and controversy regarding its results, autologous nerve grafting is still the main treatment for these type of lesions. However, due to advances in knowledge about nerve damage and with the aim of preventing the described problems of autografts, new treatment alternatives based on decellularized allografts have emerged. The aim of this systematic review was to evaluate the reported efficacy of decellularized allografts for the treatment of IAN damage. We performed a systematic search in Pubmed, Scopus and Web of Science databases following the PRISMA guidelines. Cohort studies, randomized or non-randomized clinical studies, prospective or retrospective studies, without age limits and language restriction that included human subjects who received decellularized allograft as treatment for IAN damage were included. Six articles met the inclusion criteria and were included for data analysis. In all 6 articles, resolution of IAN damage was observed in more than 85% of patients after a 12-month follow-up period, and in 2 of them, complete resolution was observed in 100% of their patients at longer follow-ups. Decellularized allograft appears to be a promising alternative to resolve IAN lesions, without requiring a nerve autograft procedure. However, more randomized clinical trials are needed to validate adequate treatment modalities with decellularized allografts.	es
dc.subject	deliver bad news	es
dc.subject	dentists	es
dc.subject	communication in health	es
dc.subject	oral cancer	es
dc.title	Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects:a systematic review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25647	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985938/