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Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma:systematic review and meta-analysis

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Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma:systematic review and meta-analysis

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dc.contributor.author González Moles, M.A. es
dc.contributor.author de Porras Carrique, Teresa es
dc.contributor.author Ramos-García, Pablo es
dc.date.accessioned 2023-06-16T08:36:54Z
dc.date.available 2023-06-16T08:36:54Z
dc.date.issued 2023 es
dc.identifier.citation González-Moles, MÁ., de Porras-Carrique, T., & Ramos-García, P. (2023). Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma: systematic review and meta-analysis. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e229-e237). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25661 es
dc.identifier.uri https://hdl.handle.net/10550/88194
dc.description.abstract Oral lichen planus (OLP) is a prevalent autoimmune chronic inflammatory disease of unknown etiology. The importance of the association between hepatic disease and OLP lies in the fact that many of these disorders (HC, HB, cirrhosis, hepatic steatosis) behave as risk factors for hepatocellular carcinoma. We searched PubMed, Embase, Web of Science, and Scopus for studies published before January 2022. We evaluated the quality of studies (Joanna Briggs Institute tool). We performed meta-analyses, investigated the heterogeneity between studies, and we also carried out subgroups, meta-regression, and small-study effects analyses. 146 studies (21,187 patients) were included in this study. Our study aims to evaluate current evidence on the prevalence and magnitude of association between hepatic diseases (especially those with risk of malignancy), hepatocellular carcinoma and OLP. Our results suggest that patients with OLP present a significant tendency to the development of hepatitis B (OR=1.62, 95%CI=1.01-2.40, p=0.02), hepatitis C (OR=4.09, 95%CI=2.77-6.03, p<0.001), cirrhosis (OR=5.58, 95%CI=1.83-16.96, p=0.002), hepatic steatosis (OR=5.71, 95%CI=0.97-33.60, p=0.05) and hepatocellular carcinoma (OR=3.10,95%CI=1.14-8.43, p=0.03). Patients with OLP should be investigated to rule out the presence of hepatic disease, which can lead to hepatocellular carcinoma, allowing an early diagnosis that would help to a better approach to liver disease and a noTable improvement in prognosis in terms of both progression and severity. es
dc.subject electric scooter es
dc.subject bicycle es
dc.subject facial injuries es
dc.subject helmet es
dc.title Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma:systematic review and meta-analysis es
dc.type journal article es_ES
dc.subject.unesco UNESCO:CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.25661 es
dc.type.hasVersion VoR es_ES
dc.identifier.url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181030/

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