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Histopathological parameters reported in microinvasive oral squamous cell carcinoma:a systematic review

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Histopathological parameters reported in microinvasive oral squamous cell carcinoma:a systematic review

dc.contributor.author	Saldivia-Siracusa, Cristina	es
dc.contributor.author	Araújo, Anna Luiza Damaceno	es
dc.contributor.author	González-Arriagada, Wilfredo	es
dc.contributor.author	Nava, Francisco Javier Tejeda	es
dc.contributor.author	Hunter, Keith	es
dc.contributor.author	Lopes, Márcio Ajudarte	es
dc.contributor.author	Vargas, Pablo Agustín	es
dc.contributor.author	Santos Silva, Alan Roger	es
dc.date.accessioned	2023-06-16T08:36:55Z
dc.date.available	2023-06-16T08:36:55Z
dc.date.issued	2023	es
dc.identifier.citation	Saldivia-Siracusa, C., Araújo, AL., González-Arriagada, WA., Nava, FJ., Hunter, KD., Lopes, MA., Vargas, PA., & Santos-Silva, AR. (2023). Histopathological parameters reported in microinvasive oral squamous cell carcinoma: a systematic review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e255-e263). Medicina Oral, S.L. https://doi.org/10.4317/medoral.25675	es
dc.identifier.uri	https://hdl.handle.net/10550/88197
dc.description.abstract	Microinvasive oral squamous cell carcinoma (OSCCmi) is an incipient stage of oral cancer. Through this systematic review, we aim to assess patterns of histopathological outcomes reported in OSCCmi cases. An online search in major databases was performed without period restriction, and 2,024 publications in English, Spanish and Portuguese were obtained. After screening and eligibility, 4 studies were selected. The risk of bias was assessed using Joanna Briggs Institute Critical Appraisal Checklist. A descriptive synthesis was conducted. All 4 publications included were retrospective, reporting a total of 116 OSCCmi patients, with a male predominance (1.6:1) and a mean age of 55.9 years. The main parameters considered for microinvasion were tumor thickness (TT) (range 4-10mm) and depth of invasion (DOI) (range 0,02-5mm). Definition, cut-off values, and assessment of microscopic features were not standardized. Other relevant measures such as perineural or lymphovascular invasion and pattern of invasive front were barely described, and cytological/architectural characteristics were not discussed. TT and DOI are currently the primary histopathological criteria used to define OSCCmi. Nonetheless, the outcomes of this systematic review showed the absence of standardized quantitative parameters to render the diagnosis of microinvasive OSCC. Therefore, additional studies aiming to standardize histopathological features to diagnose OSCCmi are paramount.	es
dc.subject	stafne bone defect	es
dc.subject	stafne	es
dc.subject	stafne defect	es
dc.title	Histopathological parameters reported in microinvasive oral squamous cell carcinoma:a systematic review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO:CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.25675	es
dc.type.hasVersion	VoR	es_ES
dc.identifier.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181028/