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Oral bisphosphonates-associated osteonecrosis in rheumatoid arthritis

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Oral bisphosphonates-associated osteonecrosis in rheumatoid arthritis

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dc.contributor.author Junquera Gutiérrez,Luis Manuel es
dc.contributor.author Gallego López,Lorena es
dc.contributor.author Coca Pelaz,Andrés es
dc.contributor.author Olay,Sonsoles es
dc.date.accessioned 2023-06-22T12:12:38Z
dc.date.available 2023-06-22T12:12:38Z
dc.date.issued 2009 es
dc.identifier.citation Junquera L, Gallego L, Pelaz A, Olay S. Oral bisphosphonates-associated osteonecrosis in rheumatoid arthritis. Med Oral Patol Oral Cir Bucal. 2009 Jun 1;14(6):E292-4. es
dc.identifier.uri https://hdl.handle.net/10550/88472
dc.description.abstract Adverse effects associated with the use of bisphosphonates are infrequent and consist of pyrexia, renal function impairment, and hypocalcemia. Bisphosphonates-associated osteonecrosis of the jaws is an uncommon but potentially serious complication of intravenous bisphosphonate therapy in cancer patients. The degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alendronate, is uncertain and warrants careful monitoring. Oral bisphosphonates-associated osteonecrosis can occur in patients with rheumatoid arthritis. We report a case of mandibular osteonecrosis in a patient who received alendronate for 3.8 years. The pathology improved after bisphosphonate therapy discontinuation and sequestrectomy. To our knowledge there are only three cases published in the literature relating bisphosphonates-associated osteonecrosis of the jaws in patients with rheumatoid arthritis. All the cases published, including our case, have reported association between methotrexate, prednisone and alendronate sodium (Fosamax®) therapy. Corticosteroid therapy and dental surgery could increase the risk of developing bisphosphonates-associated osteonecrosis of the jaws in these patients. es
dc.title Oral bisphosphonates-associated osteonecrosis in rheumatoid arthritis es
dc.type journal article es_ES
dc.subject.unesco UNESCO:CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/medoralfree01/v14i6/medoralv14i6p292.pdf

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