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Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients

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Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients

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dc.contributor.author Párraga Linares,Laura es
dc.contributor.author Almendros Marqués,Nieves es
dc.contributor.author Berini Aytés,Leonardo es
dc.contributor.author Gay-Escoda,Cosme es
dc.date.accessioned 2023-06-22T12:12:40Z
dc.date.available 2023-06-22T12:12:40Z
dc.date.issued 2009 es
dc.identifier.citation Párraga-Linares L, Almendros-Marqués N, Berini-Aytés L, Gay-Escoda C. Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients. Med Oral Patol Oral Cir Bucal. 2009 Sep 1;14(9):e429-e433. es
dc.identifier.uri https://hdl.handle.net/10550/88510
dc.description.abstract Objectives: This study aims to evaluate the effectiveness of periodontal therapy combined with tacrolimus in the suppression of gingival overgrowth (GO) and the effect on GO of changing from cyclosporin A to tacrolimus.Patients and Methods: Sixteen renal transplant patients, averaging 52 years of age, whose kidney function was stable and were receiving treatment with cyclosporin A, were randomly assigned to one of two groups. In the experimental group, patients were instructed in oral hygiene and underwent periodontal treatment, whereas in the control group, only oral hygiene instructions were given. After the first visit and the change of medication from cyclosporine to tacrolimus in both groups, periodic clinical revisions were carried out for 3 months in order to assess the evolution of GO.Results: All patients showed a progressive decrease in GO. There were no statistically significant differences between the two groups (p>0.05). A greater decrease in GO occurred within the first month after changing the medication.Conclusions: No improved effectiveness in reducing GO was observed for periodontal therapy in combination with tacrolimus. Tacrolimus is an alternative to cyclosporine when attempting to avoid GO in patients with kidney transplants. es
dc.title Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients es
dc.type journal article es_ES
dc.subject.unesco UNESCO:CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/medoralfree01/v14i9/medoralv14i9p429.pdf

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