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Hypoxic preconditioning induces neuroprotection against oxidative stress

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Hypoxic preconditioning induces neuroprotection against oxidative stress

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dc.contributor.author Millán Yáñez, Iván
dc.contributor.author Corral Debrisky, Marisol
dc.contributor.author Vento Torres, Máximo
dc.contributor.author Torres Cuevas, María Isabel
dc.date.accessioned 2023-06-22T16:27:28Z
dc.date.available 2023-06-22T16:27:28Z
dc.date.issued 2022
dc.identifier.citation Millán Yáñez, Iván Corral Debrisky, Marisol Vento Torres, Máximo Torres Cuevas, María Isabel 2022 Hypoxic preconditioning induces neuroprotection against oxidative stress Redox Experimental Medicine
dc.identifier.uri https://hdl.handle.net/10550/88516
dc.description.abstract Brain is an oxyregulator organ, however extremely vulnerable to oxygen. Both high and low oxygen concentrations generate free radicals and may cause oxidative stress and damage because of an insufficient response of the antioxidant system. Hypoxic preconditioning (HP) exerts neuroprotective effects and may be a protecting tool against oxygen fluctuations, thus preventing neuronal damage in events such as ischaemia, acute hypoxia, stroke, or traumatic brain injury, among others. This review aims to discuss the molecular mechanisms involved in the neuroprotective action of HP against oxidative stress and subsequently upon the brain under pro-oxidant conditions. Activation of the antioxidant defences represents the first line to neutralize oxidative stress and is characterized by low reactive oxygen species, reduced oxidative damage biomarkers, and increased level of reduced glutathione. These protective mechanisms decrease cell death activating anti-apoptotic signalling pathways and reducing neuroinflammation by the inactivation of microglia and astroglia cells. HP could be considered a new approach to reduce oxidative stress derived damage caused by a great variety of brain pathologies. Despite our intriguing findings, further experiments are needed for a better understanding of the molecular mechanisms involved in the neuroprotective actions of HP.
dc.relation.ispartof Redox Experimental Medicine, 2022
dc.subject Oxigen Efectes fisiològics
dc.subject Neurologia
dc.title Hypoxic preconditioning induces neuroprotection against oxidative stress
dc.type journal article
dc.date.updated 2023-06-22T16:27:28Z
dc.identifier.doi 10.1530/REM-22-0011
dc.identifier.idgrec 160655
dc.rights.accessRights open access

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