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Plasma Nickel Levels Correlate with Low Muscular Strength and Renal Function Parameters in Patients with Prostate Cancer

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Plasma Nickel Levels Correlate with Low Muscular Strength and Renal Function Parameters in Patients with Prostate Cancer

dc.contributor.author	Alegre Martínez, Antoni
dc.contributor.author	Martínez Martínez, María Isabel
dc.contributor.author	Rubio Briones, José
dc.contributor.author	Cauli, Omar
dc.date.accessioned	2023-09-05T09:27:34Z
dc.date.available	2023-09-05T09:27:34Z
dc.date.issued	2022
dc.identifier.citation	Alegre Martínez, Antoni Martínez Martínez, María Isabel Rubio Briones, José Cauli, Omar 2022 Plasma Nickel Levels Correlate with Low Muscular Strength and Renal Function Parameters in Patients with Prostate Cancer Diseases 10(39) 3 1 14
dc.identifier.uri	https://hdl.handle.net/10550/89068
dc.description.abstract	Nickel is associated with cancer in occupational exposure. However, few studies have been devoted to analyzing the effects of nickel at environmental concentrations in cancer patients. In this work, the concentration of nickel in blood samples from patients with prostate cancer (PCa) was evaluated because this metal displays androgenic and estrogenic effects that play a crucial role in prostate carcinogenesis and treatment. We, therefore, compared blood nickel concentration in patients with PCa (non-occupationally exposed) (n = 46) with those in control age-matched individuals (n = 46). We also analyzed if there was any association between sociodemographic factors, clinical variables, geriatric evaluation assessment results, blood cell counts, or biochemical, androgen and estrogen concentrations. Using inductively coupled plasma-mass spectroscopy on the plasma samples, we observed a mean nickel level of 4.97 ± 1.20 µg/L in the PCa group and 3.59 ± 0.49 µg/L in the control group, with a non-significant effect (p = 0.293) between the two groups. The nickel concentration was significantly correlated with patient age (p = 0.005) and reduced handgrip strength (p = 0.003). Regarding biochemical parameters, significant associations were found with the renal glomerular filtration rate (p = 0.024) and blood urea levels (p = 0.016). No significant correlations were observed with other blood analytical parameters or testosterone or estradiol levels. These specific renal function and muscle strength effects were observed at environmental nickel exposure levels believed to be safe or at least far from the high concentrations observed after occupational exposure. Therefore, these parameters deserve further study, given that they could help pinpoint further public health concerns regarding nickel exposure in the general population.
dc.language.iso	eng
dc.relation.ispartof	Diseases, 2022, vol. 10(39), num. 3, p. 1-14
dc.subject	Pròstata Càncer
dc.subject	Andrògens
dc.title	Plasma Nickel Levels Correlate with Low Muscular Strength and Renal Function Parameters in Patients with Prostate Cancer
dc.type	journal article
dc.date.updated	2023-09-05T09:27:34Z
dc.identifier.doi	10.3390/diseases10030039
dc.identifier.idgrec	154462
dc.rights.accessRights	open access