NAGIOS: RODERIC FUNCIONANDO

Influence of Intravitreal Therapy on Choroidal Thickness in Patients with Diabetic Macular Edema

Repositori DSpace/Manakin

Valencià Castellano

Inici
Investigació
e-prints
22 - Física
Visualitza element

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Influence of Intravitreal Therapy on Choroidal Thickness in Patients with Diabetic Macular Edema

Mostra el registre parcial de l'element

dc.contributor.author	Udaondo, Patricia
dc.contributor.author	Muñoz Morata, Carmen
dc.contributor.author	Albarrán Diego, César
dc.contributor.author	España Gregori, Enrique
dc.date.accessioned	2023-09-06T10:00:25Z
dc.date.available	2023-09-06T10:00:25Z
dc.date.issued	2023
dc.identifier.citation	Udaondo, Patricia Muñoz Morata, Carmen Albarrán Diego, César España Gregori, Enrique 2023 Influence of Intravitreal Therapy on Choroidal Thickness in Patients with Diabetic Macular Edema Journal Of Clinical Medicine 12 1 12
dc.identifier.uri	https://hdl.handle.net/10550/89112
dc.description.abstract	Objective: This study aimed to analyze the variation in subfoveal choroidal thickness (SFCT) and its relationship with the variation in central macular thickness (CME) in response to intravitreal therapy with an antiangiogenic (anti-VEGF) drug or corticosteroid in type 2 diabetic patients with diabetic macular edema (DME). Material and methods: This retrospective study included 70 eyes of 35 patients: 26 eyes received 4−5 intravitreal injections of aflibercept, 26 eyes were treated with a single intravitreal implant injection of dexamethasone, and 18 eyes without DME did not receive intravitreal therapy. SPECTRALIS®optical coherence tomography (OCT) (Heidelberg Engineering, Heidelberg, Germany) was used to measure the SFCT and CME before and at the end of the follow-up period. Results: The mean reductions in CME were 18.8 +/− 14.7% (aflibercept) and 29.7 +/− 16.9% (dexamethasone). The mean reductions in SFCT were 13.8 +/− 13.1% (aflibercept) and 19.5 +/− 9.6% (dexamethasone). The lowering effects of both parameters were significantly greater in the group treated with the dexamethasone implant (p = 0.022 and p = 0.046 for CMT and SFCT, respectively). Both therapies significantly decreased both CME and SFCT, independent of factors such as age, sex, previous intravitreal therapy, antidiabetic treatment, and the time of diabetes progression. There were no changes in the mean values of CME and SFCT in the untreated eyes. Conclusions: SFCT significantly decreased in response to intravitreal therapy with anti-VEGF or corticosteroids, irrespective of age, sex, previous intravitreal therapy, antidiabetic treatment, and the time of diabetes progression. There was a correlation between the changes in CME and SFCT after intravitreal therapy with aflibercept or dexamethasone implantation. SFCT was not a good predictor of the CME response but could be used to monitor the response to treatment. Local intravitreal therapy only affected the treated eye.
dc.language.iso	eng
dc.relation.ispartof	Journal Of Clinical Medicine, 2023, vol. 12, p. 1-12
dc.subject	Òptica
dc.subject	Optometria
dc.title	Influence of Intravitreal Therapy on Choroidal Thickness in Patients with Diabetic Macular Edema
dc.type	journal article
dc.date.updated	2023-09-06T10:00:25Z
dc.identifier.doi	10.3390/jcm12010348
dc.identifier.idgrec	160868
dc.rights.accessRights	open access