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Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study

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Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study

dc.contributor.author	Solano de la Asunción, Carlos
dc.contributor.author	Giménez, Estela
dc.contributor.author	Hernández Boluda, Juan Carlos
dc.contributor.author	Terol, Maria José
dc.contributor.author	Albert, Eliseo
dc.contributor.author	López, Javier
dc.contributor.author	García Gutiérrez, Valentín
dc.contributor.author	Andreu, Rafael
dc.contributor.author	García Malo, María Dolores
dc.contributor.author	Fox, María Laura
dc.contributor.author	Remigia, María José
dc.contributor.author	Amat Martínez, Paula
dc.contributor.author	Solano Vercet, Carlos
dc.contributor.author	Navarro, David
dc.date.accessioned	2023-09-11T12:52:31Z
dc.date.available	2023-09-11T12:52:31Z
dc.date.issued	2023
dc.identifier.citation	Solano de la Asunción, Carlos Giménez, Estela Hernández Boluda, Juan Carlos Terol, Maria José Albert, Eliseo López, Javier García Gutiérrez, Valentín Andreu, Rafael García Malo, María Dolores Fox, María Laura Remigia, María José Amat Martínez, Paula Solano Vercet, Carlos Navarro, David 2023 Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study Journal of Medical Virology 95 7
dc.identifier.uri	https://hdl.handle.net/10550/89190
dc.description.abstract	It is unknown whether Torque Teno virus (TTV) DNA load monitoring could anticipate the development of infectious events in hematological patients undergoing treatment with small molecular targeting agents. We characterized the kinetics of plasma TTV DNA in patients treated with ibrutinib or ruxolitinib and assessed whether TTV DNA load monitoring could predict the occurrence of Cytomegalovirus (CMV) DNAemia or the magnitude of CMV-specific T-cell responses. Multicenter, retrospective, observational study, recruiting 20 patients treated with ibrutinib and 21 with ruxolitinib. Plasma TTV and CMV DNA loads were quantified by real-time PCR at baseline and days +15, +30, +45, +60, +75, +90, +120, +150, and +180 after treatment inception. Enumeration of CMV-specific interferon-γ (IFN-γ)-producing CD8+ and CD4+ T-cells in whole blood was performed by flow cytometry. Median TTV DNA load in ibrutinib-treated patients increased significantly (p = 0.025) from baseline (median: 5.76 log10 copies/mL) to day +120 (median: 7.83 log10 copies/mL). A moderate inverse correlation (Rho = -0.46; p < 0.001) was found between TTV DNA load and absolute lymphocyte count. In ruxolitinib-treated patients, TTV DNA load quantified at baseline was not significantly different from that measured after treatment inception (p ≥ 0.12). TTV DNA load was not predictive of the subsequent occurrence of CMV DNAemia in either patient group. No correlation was observed between TTV DNA loads and CMV-specific IFN-γ-producing CD8+ and CD4+ T-cell counts in either patient group. The data did not support the hypothesis that TTV DNA load monitoring in hematological patients treated with ibrutinib or ruxolitinib could be useful to predict either the occurrence of CMV DNAemia or the level of CMV-specific T-cell reconstitution; nevertheless, due to the small sample size, further studies involving larger cohorts are warranted to elucidate this issue. Keywords: CMV; CMV DNAemia; CMV-specific T-cells; Ibrutinib; TTV DNA load; ruxolitinib.
dc.language.iso	eng
dc.relation.ispartof	Journal of Medical Virology, 2023, vol. 95, num. 7
dc.subject	Microbiologia
dc.subject	Patologia
dc.title	Assessment of the potential value of plasma Torque Teno virus DNA load monitoring to predict cytomegalovirus DNAemia in patients with hematological malignancies treated with small molecule inhibitors: A proof-of-concept study
dc.type	journal article
dc.date.updated	2023-09-11T12:52:32Z
dc.identifier.doi	10.1002/jmv.28933
dc.identifier.idgrec	161156
dc.rights.accessRights	open access