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Quantifying the available capacity and resource needs for provision of CAR-T therapies in the National Health Service in Spain: a survey-based study

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Quantifying the available capacity and resource needs for provision of CAR-T therapies in the National Health Service in Spain: a survey-based study

dc.contributor.author	Solano Vercet, Carlos
dc.contributor.author	Castro Rebollo, Pedro
dc.contributor.author	Pérez Martínez, Antonio
dc.contributor.author	López Corral, Lucía
dc.contributor.author	Barba Suñol, Pere
dc.contributor.author	Kwon, Mi
dc.contributor.author	Ortiz, Valentín
dc.contributor.author	Sanz Caballer, Jaime
dc.contributor.author	Caballero, Ana Carolina
dc.contributor.author	Martínez, Joaquín
dc.contributor.author	Cedillo, Ángel
dc.contributor.author	Sureda, Anna
dc.date.accessioned	2023-09-12T10:00:37Z
dc.date.available	2023-09-12T10:00:37Z
dc.date.issued	2023
dc.identifier.citation	Solano Vercet, Carlos Castro Rebollo, Pedro Pérez Martínez, Antonio López Corral, Lucía Barba Suñol, Pere Kwon, Mi Ortiz, Valentín Sanz Caballer, Jaime Caballero, Ana Carolina Martínez, Joaquín Cedillo, Ángel Sureda, Anna 2023 Quantifying the available capacity and resource needs for provision of CAR-T therapies in the National Health Service in Spain: a survey-based study Bmj Open 13 7
dc.identifier.uri	https://hdl.handle.net/10550/89215
dc.description.abstract	Objectives: To estimate the readiness of Spanish National Health Service (NHS) hospitals to provide chimeric antigen receptor T cell (CAR-T), and to identify and quantify the different resources needed to provide CAR-T considering three scenarios defined by 10, 25 and 50 patients per centre per year. Design: Targeted literature review and quantitative study using a questionnaire and telephone interviews. An algorithm was created to determine hospitals' readiness based on their capacity and capability. All the requirements for quantification were assessed and validated by the steering committee, formed by members of the Spanish Group of Haematopoietic Transplantation and Cell Therapy. A weighting system (from 0 to 1) was established for capability quantification. For resources quantification, a scoring system was established, with 0 points representing the minimum and 3 points the maximum of additional resources that a hospital indicated necessary. Setting: 40 Spanish hospital centres that perform allogeneic haematopoietic stem cell transplantation were invited to complete the questionnaire for capacity quantification, 28 of which provided valid responses. Nine hospitals participated in the interviews for resource quantification, eight of which had previously been designated by the Ministry of Health (MoH) to provide CAR-T. Outcome measure: Current capacity of NHS Spanish sites to administer CAR-T under different theoretical scenarios with varying numbers of procedures, and the potential healthcare resources that would be needed to realise the theoretical capacity requirements. Results: Four hospitals were optimally ready, 17 were somewhat ready and 7 were not ready. The actual extrapolated capacity of the currently designated MoH CAR-T sites would allow treatment of approximately 250 patients per year. Regarding healthcare resource needs, the numbers of haematologists, nurses and beds were the most important limiting factors, and those requiring further growth as patient numbers increased. Conclusions: Increasing the number of CAR-T-qualified centres and/or increasing resources in the current designated sites are two potential strategies that should be considered to treat CAR-T-eligible patients in Spain.
dc.language.iso	eng
dc.relation.ispartof	Bmj Open, 2023, vol. 13, num. 7
dc.subject	Patologia
dc.subject	Salut pública Planificació
dc.title	Quantifying the available capacity and resource needs for provision of CAR-T therapies in the National Health Service in Spain: a survey-based study
dc.type	journal article
dc.date.updated	2023-09-12T10:00:37Z
dc.identifier.doi	10.1136/bmjopen-2022-071371
dc.identifier.idgrec	161155
dc.rights.accessRights	open access