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Protective action of ultrasound-guided electrolysis technique on the muscle damage induced by notexin in rats

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Protective action of ultrasound-guided electrolysis technique on the muscle damage induced by notexin in rats

dc.contributor.author	Jordá Vallés, Adrián
dc.contributor.author	Campos Campos, Juan
dc.contributor.author	Aldasoro, Constanza
dc.contributor.author	Colmena Zaragoza, Carlos Manuel
dc.contributor.author	Aldasoro Celaya, Martín
dc.contributor.author	Álvarez, Kenia
dc.contributor.author	Vallés Martí, Lilián Soraya
dc.date.accessioned	2023-09-13T07:50:18Z
dc.date.available	2023-09-13T07:50:18Z
dc.date.issued	2022
dc.identifier.citation	Jordá Vallés, Adrián Campos Campos, Juan Aldasoro, Constanza Colmena Zaragoza, Carlos Manuel Aldasoro Celaya, Martín Álvarez, Kenia Vallés Martí, Lilián Soraya 2022 Protective action of ultrasound-guided electrolysis technique on the muscle damage induced by notexin in rats Plos One
dc.identifier.uri	https://hdl.handle.net/10550/89221
dc.description.abstract	It is known that exercise can be one of the causes of muscular damage. In recent times, physiotherapists and medical professionals have been employing USGET techniques to stimulate muscle recovery to improve its performance after the injury. We pretend to analyse if the Ultrasound-guided electrolysis (USGET) technique could reduce muscle damage, inflammation, and pain in the present study. Female Wistar rats were assigned to one of three different groups: control (C), notexin (NOT) and notexin with USGET (electrolysis at 6mA) (NOT+USGET). We used the USGT technique, based on electrical stimulation with a continuous current of 4 pulses at an intensity of 6 mA for 5 seconds, conveyed to the muscle. The response was tested with motor function tests. In these tests, we could observe an increase in time and foot faults when crossing a beam in the NOT group compared to C group rats. On the other hand, a significant decrease in both variables was detected in the NOT+USGET compared to the NOT group. Muscle power was measured with a grip strength test, obtaining far better performances in NOT+USGET rats when compared to NOT rats. Moreover, the USGET technique prevented the increase of pro-inflammatory proteins IL-6 and chemokines CCL3 (Chemokine (C-C motif) ligand 3), CCL4 (Chemokine (C-C motif) ligand 4), and CCL5 (Chemokine (C-C motif) ligand 5) with their receptor CCR5 (C-C chemokine receptor type 5), induced by notexin in the quadriceps. At the same time, the study evidenced a decrease in both CCR8 (C-C chemokine receptor type 5,) and NF-ᴋB (nuclear factor- ᴋB) expressions after USGET treatment. On the other hand, we obtained evidence that demonstrated anti-inflammatory properties of the USGET technique, thus being the increase in IL-10 (Interleukin 10) and IL-13 (Interleukin 13) in the NOT+USGET group compared to the NOT group. Furthermore, when applying NSGET after damage, an increase in anti-inflammatory mediators and reduction of pro-inflammatory mediators, which, overall, promoted muscle regeneration, was observed. These results support the idea that the NSGET technique improves muscle recovery after toxic damages, which would justify its employment.
dc.language.iso	spa
dc.relation.ispartof	Plos One, 2022
dc.subject	Fisioteràpia
dc.subject	Rehabilitació
dc.title	Protective action of ultrasound-guided electrolysis technique on the muscle damage induced by notexin in rats
dc.type	journal article
dc.date.updated	2023-09-13T07:50:19Z
dc.identifier.doi	10.1371/journal.pone.0276634
dc.identifier.idgrec	155820
dc.rights.accessRights	open access