Investigations on the prevalence of pulp and periradicular diseases in Mexican population produced few studies, conducted to specific age population. Considering the importance of epidemiological investigation.The aim of this study was to estimate the prevalence of pulp and periapical pathologies and their distribution according to sex, age, affected teeth, and etiological factors found in patients the DEPeI, FO, UNAM Endodontic Postgraduate Program during the period 2014–2019.The data collected were from the records of the Single Clinical File of patients treated at the Endodontic Specialization Clinic, DEPeI, FO, UNAM, period 2014–2019. The following variables were recorded for each endodontic file: diagnosed pulp and periapical pathology, sex, age, affected tooth, and etiological factor. Descriptive statistical analysis was performed with 95% CI (Confidence intervals).Of all the registers reviewed, irreversible pulpitis (34.58%) and chronic apical periodontitis (34.89%) proved to be the most prevalent pulp and periapical pathologies, respectively. The female sex predominated (65.36%). The age group that requested the most endodontic treatment, according to the records reviewed, was 60 or older (36.99%). The most treated teeth were the upper first molars (24.15%) and lower (36.71%), and the most prevalent etiological factor was dental caries (84.07%).Irreversible pulpitis and chronic apical periodontitis were the most prevalent pathologies. The predominant sex was female, and the age group was 60 years or older. The first upper and lower molars were the most endodontically treated teeth. The most prevalent etiological factor was dental caries.