To evaluate the in vitro degree of marginal microleakage in indirect Class II onlay restorations cemented with dual self-adhesive, universal adhesive and dual adhesive.In the present in vitro experimental study, a total of 54 human premolar teeth were prepared and divided into three equal groups (n = 18) for placement of onlay-type restorations cemented with A: Allcem™ dual-cure adhesive cement), B: RelyX™U200 dual-cure self-adhesive cement and C: RelyX™ Ultimate universal adhesive cement. All restorations were subjected to 10,000 thermocycles between 5°C and 55°C and immersed in a 1M silver nitrate solution for 6 hours. The crowns were then sectioned mesiodistally and observed under a stereo microscope to determine the degree of marginal microleakage in the cervical area.The onlay restorations cemented with RelyX Ultimate did not present microleakage in the majority of cases (77.8%). Restorations cemented with RelyX U200 showed predominantly microleakage up to the pulp floor in 83.3% of the total, being this significantly higher microleakage than in restorations cemented with RelyX Ultimate and Allcem Dual (p<0.001 and p<0.001 respectively). There was no significant difference in microleakage between the last two mentioned cements (p=0.255) Allcem dual adhesive cement and RelyX Ultimate universal adhesive showed significantly less microleakage than RelyX U200 dual-curing self-adhesive cement at the cervical level, with predominantly no microleakage and microleakage down to the enamel, respectively. The use of RelyX Ultimate cement in indirect restorations is recommended as it showed better marginal adaptation.