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Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)

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Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)

dc.contributor.author	Herranz Pérez, Vicente
dc.contributor.author	Parcerisas, Antoni
dc.contributor.author	Hino, Keiko
dc.contributor.author	Ortega Gascó, Alba
dc.contributor.author	Ulloa, Fausto
dc.contributor.author	Elias Tersa, Alba
dc.contributor.author	Bosch, Miquel
dc.contributor.author	García Verdugo, José Manuel
dc.contributor.author	Simó, Sergi
dc.contributor.author	Pujadas, Lluís
dc.contributor.author	Soriano, Eduardo
dc.date.accessioned	2023-09-27T10:09:45Z
dc.date.available	2023-09-27T10:09:45Z
dc.date.issued	2023
dc.identifier.citation	Herranz Pérez, Vicente Parcerisas, Antoni Hino, Keiko Ortega Gascó, Alba Ulloa, Fausto Elias Tersa, Alba Bosch, Miquel García Verdugo, José Manuel Simó, Sergi Pujadas, Lluís Soriano, Eduardo 2023 Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2) Cerebral Cortex 1 18
dc.identifier.uri	https://hdl.handle.net/10550/89664
dc.description.abstract	Adult neurogenesis persists in mammals in the neurogenic zones, where newborn neurons are incorporated into preexisting circuits to preserve and improve learning and memory tasks. Relevant structural elements of the neurogenic niches include the family of cell adhesion molecules (CAMs), which participate in signal transduction and regulate the survival, division, and differentiation of radial glial progenitors (RGPs). Here we analyzed the functions of neural cell adhesion molecule 2 (NCAM2) in the regulation of RGPs in adult neurogenesis and during corticogenesis. We characterized the presence of NCAM2 across the main cell types of the neurogenic process in the dentate gyrus, revealing different levels of NCAM2 amid the progression of RGPs and the formation of neurons. We showed that Ncam2 overexpression in adult mice arrested progenitors in an RGP-like state, affecting the normal course of young-adult neurogenesis. Furthermore, changes in Ncam2 levels during corticogenesis led to transient migratory deficits but did not affect the survival and proliferation of RGPs, suggesting a differential role of NCAM2 in adult and embryonic stages. Our data reinforce the relevance of CAMs in the neurogenic process by revealing a significant role of Ncam2 levels in the regulation of RGPs during young-adult neurogenesis in the hippocampus.
dc.language.iso	eng
dc.relation.ispartof	Cerebral Cortex, 2023, p. 1-18
dc.subject	Biologia
dc.subject	Biologia humana
dc.subject	Antropologia física
dc.title	Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
dc.type	journal article
dc.date.updated	2023-09-27T10:09:46Z
dc.identifier.doi	10.1093/cercor/bhad340
dc.identifier.idgrec	161279
dc.rights.accessRights	open access