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Monitoring of plasma Torque teno virus, total Anelloviridae and Human Pegivirus 1 viral load for the prediction of infectious events and acute graft versus host disease in the allogeneic hematopoietic stem cell transplantation setting

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Monitoring of plasma Torque teno virus, total Anelloviridae and Human Pegivirus 1 viral load for the prediction of infectious events and acute graft versus host disease in the allogeneic hematopoietic stem cell transplantation setting

dc.contributor.author	Forqué Rodríguez, Lorena
dc.contributor.author	Albert, Eliseo
dc.contributor.author	Piñana, José Luis
dc.contributor.author	Pérez, Ariadna
dc.contributor.author	Hernani Morales, Rafael
dc.contributor.author	Solano Vercet, Carlos
dc.contributor.author	Navarro Ortega, David
dc.contributor.author	Giménez Quiles, Estela Berenice
dc.date.accessioned	2023-10-16T16:16:36Z
dc.date.available	2023-10-16T16:16:36Z
dc.date.issued	2023
dc.identifier.citation	Forqué Rodríguez, Lorena Albert, Eliseo Piñana, José Luis Pérez, Ariadna Hernani Morales, Rafael Solano Vercet, Carlos Navarro Ortega, David Giménez Quiles, Estela Berenice 2023 Monitoring of plasma Torque teno virus, total Anelloviridae and Human Pegivirus 1 viral load for the prediction of infectious events and acute graft versus host disease in the allogeneic hematopoietic stem cell transplantation setting Journal of Medical Virology 95 9
dc.identifier.uri	https://hdl.handle.net/10550/90372
dc.description.abstract	Anelloviridae and Human Pegivirus 1 (HPgV-1) blood burden have been postulated to behave as surrogate markers for immunosuppression in transplant recipients. Here, we assessed the potential utility plasma Torque teno virus (TTV), total Anelloviridae (TAV), and HPgV-1 load monitoring for the identification of allogeneic hematopoietic stem cell transplantation recipients (allo-HSCT) at increased risk of infectious events or acute graft versus host disease (aGvHD). In this single-center, observational study, plasma TTV DNA, TAV DNA, and HPgV-1 RNA loads were monitored in 75 nonconsecutive allo-HSCT recipients (median age, 54 years). Monitoring was conducted before at baseline or by days +30, +60, +90, +120, and +180 after transplantation. Pneumonia due to different viruses or Pneumocystis jirovecii, BK polyomavirus-associated haemorrhagic cystitis (BKPyV-HC), and Cytomegalovirus DNAemia were the infectious events considered in the current study. Kinetics of plasma TTV, TAV DNA, and HPgV-1 RNA load was comparable, with though and peak levels measured by days +30 and day +90 (+120 for HPgV-1). Forty patients (53%) developed one or more infectious events during the first 180 days after allo-HSCT, whereas 29 patients (39%) had aGvHD (grade II-IV in 18). Neither, TTV, TAV, nor HPgV-1 loads were predictive of overall infection or CMV DNAemia. A TTV DNA load cut-off ≥4.40 log10 (pretransplant) and ≥4.58 log10 (baseline) copies/mL predicted the occurrence of BKPyV-HC (sensitivity ≥89%, negative predictive value, ≥96%). TTV DNA loads ≥3.38 log10 by day +30 anticipated the occurrence of aGvHD (sensitivity, 90%; negative predictive value, 97%). Pretransplant HPgV-1 loads were significantly lower (p = 0.03) in patients who had aGvHD than in those who did not. Monitoring of TTV DNA or HPgV-1 RNA plasma levels either before or early after transplantation may be ancillary to identify allo-HSCT recipients at increased risk of BKPyV-HC or aGvHD.
dc.relation.ispartof	Journal of Medical Virology, 2023, vol. 95, num. 9
dc.subject	Virus
dc.subject	Malalties
dc.title	Monitoring of plasma Torque teno virus, total Anelloviridae and Human Pegivirus 1 viral load for the prediction of infectious events and acute graft versus host disease in the allogeneic hematopoietic stem cell transplantation setting
dc.type	journal article
dc.date.updated	2023-10-16T16:16:36Z
dc.identifier.doi	10.1002/jmv.29107
dc.identifier.idgrec	161469
dc.rights.accessRights	open access