The article gives an account of the result of the research developed in response to the call made by the International Labour Organization (ILO) and the Open Society Foundations (OSF) in 2021 to carry out a project that would identify the potential of the link between unions and cooperatives to organize workers in the informal economy in African and Latin American countries. Researchers from ODI, London, with the collaboration of researchers and practitioners from Brazil, Colombia, Ghana, Kenya and Uganda, identified and documented partnership examples through which to shed light development processes, identify learning on successes and challenges, and inform recommendations for future support. A country case study of Colombia is provided to illustrate the variety, complexity and possibilities of the topic studied. Three nascent partnership experiences, linked in different ways to the social and solidarity economy, demonstrate the potential of this approach to promote fair trade, responsible consumption and local markets, boost entrepreneurship and create decent working conditions for workers who traditionally face informality.