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Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study

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Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study

dc.contributor.author	Peris Martínez, Cristina
dc.contributor.author	Piá-Ludeña, José-Vicente
dc.contributor.author	Rog-Revert, María-José
dc.contributor.author	Fernández-López, Ester
dc.contributor.author	Domingo, Joan-Carles
dc.date.accessioned	2023-11-03T19:16:54Z
dc.date.available	2023-11-03T19:16:54Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/90952
dc.description.abstract	A prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I-III (Amsler-Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. A panel of fatty acids in blood samples was also assessed. There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. Additionally, between-group significant differences in total antioxidant capacity (TAC), malondialdehyde (MDA), free glutathione (GSH) and GSH/GSSG ratio, as well as reduced values of inflammatory markers, including interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF-A) were found. These preliminary findings support the usefulness of the antioxidant and anti-inflammatory effects of DHA supplementation for targeting underlying pathophysiological mechanisms of keratoconus. Prolonged duration of DHA supplementation may be needed to detect more noticeable clinical changes in corneal topography.
dc.language.iso	eng
dc.relation.ispartof	Nutrients, 2023
dc.source	Peris Martínez, Cristina Piá-Ludeña, José-Vicente Rog-Revert, María-José Fernández-López, Ester Domingo, Joan-Carles 2023 Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study Nutrients
dc.subject	Ulls Malalties i defectes
dc.title	Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study
dc.type	journal article
dc.date.updated	2023-11-03T19:16:55Z
dc.identifier.doi	10.3390/nu15051300
dc.identifier.idgrec	161698
dc.rights.accessRights	open access