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The Role of Aryl Hydrocarbon Receptor in the Endothelium : A Systematic Review

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The Role of Aryl Hydrocarbon Receptor in the Endothelium : A Systematic Review

dc.contributor.author	Guerra Ojeda, Sol
dc.contributor.author	Suárez-Fortea, Andrea
dc.contributor.author	Valls-Arrufat, Alicia
dc.contributor.author	Verdú, David
dc.contributor.author	Pereda Cervera, Javier
dc.contributor.author	Ortiz Zapater, Elena
dc.contributor.author	Carretero Asunción, Julián
dc.contributor.author	Mauricio Aviñó, María Dolores
dc.contributor.author	Serna García, Eva
dc.date.accessioned	2023-11-06T14:24:14Z
dc.date.available	2023-11-06T14:24:14Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/90965
dc.description.abstract	Activation of the aryl hydrocarbon receptor (AhR) has been shown to be important in physiological processes other than detoxification, including vascular homeostasis. Although AhR is highly expressed in the endothelium, its function has been poorly studied. This systematic review aims to summarise current knowledge on the AhR role in the endothelium and its cardiovascular implications. We focus on endogenous AhR agonists, such as some uremic toxins and other agonists unrelated to environmental pollutants, as well as studies using AhR knockout models. We conclude that AhR activation leads to vascular oxidative stress and endothelial dysfunction and that blocking AhR signalling could provide a new target for the treatment of vascular disorders such as cardiovascular complications in patients with chronic kidney disease or pulmonary arterial hypertension.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2023
dc.source	Guerra Ojeda, Sol Suárez-Fortea, Andrea Valls-Arrufat, Alicia Verdú, David Pereda Cervera, Javier Ortiz Zapater, Elena Carretero Asunción, Julián Mauricio Aviñó, María Dolores Serna García, Eva 2023 The Role of Aryl Hydrocarbon Receptor in the Endothelium : A Systematic Review International Journal Of Molecular Sciences
dc.subject	Sistema cardiovascular
dc.title	The Role of Aryl Hydrocarbon Receptor in the Endothelium : A Systematic Review
dc.type	journal article
dc.date.updated	2023-11-06T14:24:14Z
dc.identifier.doi	10.3390/ijms241713537
dc.identifier.idgrec	161675
dc.rights.accessRights	open access